Artemisinin resistance is a major threat to global malaria control and elimination efforts. Myanmar detected the first indication of the resistance in 2009 in the eastern part of the country, bordering Thailand. Since 2010, WHO has played a vital role in ensuring that a comprehensive programme on the containment of the resistance is in place. This paper documents achievement made in terms of output, outcomes and early impact on malaria from July 2011 to December 2013. It also identifies enabling factors to success and, most importantly, challenges awaiting the national programme and its partners.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.4103/2224-3151.206893 | DOI Listing |
The emergence of parasites partially resistant to artemisinins (ART-R) poses a significant threat to recent gains in malaria control. ART-R has been associated with PfKelch13 (K13) mutations, which differ in fitness costs. This study investigates the gametocyte production and transmission fitness of African and Asian isolates with different K13 genotypes across multiple mosquito species.
View Article and Find Full Text PDFNew Microbes New Infect
February 2025
Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Environ Pollut
January 2025
Department of Environmental Science and Engineering, University of Science and Technology of China, Hefei 230026, China. Electronic address:
The co-existence of microplastics (MPs) and organic pollutants on agricultural ecosystems pose potential implications for both food safety and environmental integrity. The combined effects of MPs with Dechlorane Plus (DP), a newly listed banned flame retardant, remain unknown. This study explores the biological responses of soybean plants to exposure from polyethylene (PE) and polyvinyl chloride (PVC) MPs and DP.
View Article and Find Full Text PDFInt J Parasitol Drugs Drug Resist
December 2024
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21210, USA. Electronic address:
Fosmidomycin and clindamycin target the Plasmodium apicoplast. Combination clinical trials have produced mixed results with the primary problem being the recrudescent infection frequency by day 28. Given that antibiotic efficacy against bacterial infections often depends on the constant drug presence over several days, we hypothesized that the antimalarial blood or liver stage efficacy of fosmidomycin and clindamycin could be improved by implementing a more frequent dosing schedule.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!