AI Article Synopsis
- Stress hormones can affect memory, sometimes enhancing it and other times impairing it.
- A study showed that a low daily dose of methylprednisolone (5mg/kg) for 10 days improved aversive memory in adult rats, with no impact on their general behavior or anxiety.
- The enhanced memory performance was linked to long-term potentiation in the hippocampus and increased calcium levels in hippocampal neurons after exposure to methylprednisolone.
Article Abstract
It is well recognized that stress or glucocorticoids hormones treatment can modulate memory performance in both directions, either impairing or enhancing it. Despite the high number of studies aiming at explaining the effects of glucocorticoids on memory, this has not yet been completely elucidated. Here, we demonstrate that a low daily dose of methylprednisolone (MP, 5mg/kg, i.p.) administered for 10-days favors aversive memory persistence in adult rats, without any effect on the exploring behavior, locomotor activity, anxiety levels and pain perception. Enhanced performance on the inhibitory avoidance task was correlated with long-term potentiation (LTP), a phenomenon that was strengthen in hippocampal slices of rats injected with MP (5mg/kg) during 10days. Additionally, in vitro incubation with MP (30-300µM) concentration-dependently increased intracellular [Ca] in cultured hippocampal neurons depolarized by KCl (35mM). In conclusion, a low daily dose of MP for 10days may promote aversive memory persistence in rats.
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| http://dx.doi.org/10.1016/j.brainres.2017.06.007 | DOI Listing |
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