Using an iridium catalyst modified by PhanePhos, CF-allenes react with methanol to form branched products of hydrohydroxymethylation as single regioisomers with excellent levels of enantiomeric enrichment. This hydrogen autotransfer process enables catalytic enantioselective formation of acyclic CF-bearing all-carbon quaternary stereocenters in the absence of stoichiometric metals or byproducts.
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| http://dx.doi.org/10.1021/jacs.7b04374 | DOI Listing |
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