This communication describes the anti-platelet effects of a new class of cis-rhenium(ii)-dicarbonyl-vitamin B complexes (B-ReCORMs) with tuneable CO releasing properties.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c7cc03642fDOI Listing

Publication Analysis

Top Keywords

modified biovectors
4
biovectors tuneable
4
tuneable activation
4
activation anti-platelet
4
anti-platelet carbon
4
carbon monoxide
4
monoxide release
4
release communication
4
communication describes
4
describes anti-platelet
4

Similar Publications

Optimizing the Therapeutic Index of sdAb-Based Radiopharmaceuticals Using Pretargeting.

J Nucl Med

October 2024

Institut de Recherche en Cancérologie de Montpellier, Université de Montpellier, INSERM, U1194, Équipe labellisée Ligue contre le cancer, Montpellier, France; and

Single-domain antibodies (sdAbs) demonstrate favorable pharmacokinetic profiles for molecular imaging applications. However, their renal excretion and retention are obstacles for applications in targeted radionuclide therapy (TRT). Using a click-chemistry-based pretargeting approach, we aimed to reduce kidney retention of a fibroblast activation protein α (FAP)-targeted sdAb, 4AH29, for Lu-TRT.

View Article and Find Full Text PDF

Spore-forming pathogens like Clostridioides difficile depend on germination to initiate infection. During gemination, spores must degrade their cortex layer, which is a thick, protective layer of modified peptidoglycan. Cortex degradation depends on the presence of the spore-specific peptidoglycan modification, muramic-∂-lactam (MAL), which is specifically recognized by cortex lytic enzymes.

View Article and Find Full Text PDF

This communication describes the anti-platelet effects of a new class of cis-rhenium(ii)-dicarbonyl-vitamin B complexes (B-ReCORMs) with tuneable CO releasing properties.

View Article and Find Full Text PDF
Article Synopsis
  • Researchers created mixed CO/NO-releasing molecules by attaching a rhenium complex to modified vitamin B12 molecules.
  • These new compounds were thoroughly analyzed using techniques like X-ray crystallography.
  • When tested, the B12 derivatives showed the ability to release low doses of nitric oxide in solution and provided some protective effects in cell models, but did not enhance the effects more than their individual components.
View Article and Find Full Text PDF

BioVector, a flexible system for gene specific-expression in plants.

BMC Plant Biol

December 2013

MOA Key Lab of Soybean Biology (Beijing), National Key Facility of Crop Gene Resource and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, 12 Zhongguancun Nandajie, Haidian District, Beijing 100081, China.

Background: Functional genomic research always needs to assemble different DNA fragments into a binary vector, so as to express genes with different tags from various promoters with different levels. The cloning systems available bear similar disadvantages, such as promoters/tags are fixed on a binary vector, which is generally with low cloning efficiency and limited for cloning sites if a novel promoter/tag is in need. Therefore, it is difficult both to assemble a gene and a promoter together and to modify the vectors in hand.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!