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Assessing cardiovascular toxicity in zebrafish embryos exposed to copper nanoparticles.
Comp Biochem Physiol C Toxicol Pharmacol
March 2024
Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan. Electronic address:
The toxicity of copper nanoparticles (CuNPs) to aquatic animals, particularly their effects on the cardiovascular system, has not been thoroughly investigated. In the present study, zebrafish embryos were used as a model to address this issue. After exposure to different concentrations (0.
View Article and Find Full Text PDFDevelopment of a Microgram Scale Video-Microscopic Method to Investigate Dissolution Behavior of Poorly Water-Soluble Drugs.
AAPS PharmSciTech
June 2022
Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen Ø, Denmark.
Poor aqueous solubility is a common characteristic of new drug candidates, which leads to low or inconsistent oral bioavailability. This has sparked an interest in material efficient testing of solubility and dissolution rate. The aim was to develop a microgram scale video-microscopic method to screen the dissolution rates of poorly water-soluble drugs.
View Article and Find Full Text PDFNew Triazacycloalkane Derivatives as Cytotoxic Agents for CLL Treatment: From Proof of Concept to the Targeting Biomolecule.
Bioconjug Chem
July 2022
Univ. Brest, UMR-CNRS 6521 CEMCA, 6 Avenue Victor le Gorgeu, 29238 Brest, France.
The 1,4,7-tris-(2-pyridinylmethyl)-1,4,7-triazacyclononane ligand () and its bifunctional analogue were synthesized to investigate their action toward zinc(II) depletion related to the apoptosis phenomenon in chronic lymphocytic leukemia (CLL) cells. was used as the "free" ligand, while its "graftable" derivative was conjugated on a newly synthesized bifunctional sialoglycan, , selected to specifically bind CD22 biomarker expressed on the B-CLL cell surface. Both compounds were produced with good yields thanks to a Sonogashira coupling reaction and an orthoester function, respectively, for the chelator and the targeting moiety.
View Article and Find Full Text PDFIs microcirculatory assessment ready for regular use in clinical practice?
Curr Opin Crit Care
June 2019
Department of Intensive Care, CHIREC Hospitals, Université Libre de Bruxelles, Brussels, Belgium.
Purpose Of Review: The present review discusses the current role of microcirculatory assessment in the hemodynamic monitoring of critically ill patients.
Recent Findings: Videomicroscopic techniques have demonstrated that microvascular perfusion is altered in critically ill patients, and especially in sepsis. These alterations are associated with organ dysfunction and poor outcome.
In vivo quantification of rolling and adhered leukocytes in human sepsis.
Crit Care
September 2018
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 1 Deaconess Road, CC2-W, Boston, MA, 02215, USA.
Background: The use of in vivo videomicroscopy at the bedside has demonstrated microcirculatory flow disturbances in sepsis. The ability of in vivo videomicroscopy to detect changes in the prevalence of rolling and adhered leukocytes that occur in sepsis is not well-described in humans. We sought to (1) develop methodology for accessing and quantifying sublingual leukocyte rolling and adherence with sidestream dark field (SDF) imaging; (2) compare the number of rolling and adhered leukocytes between patients with septic shock and non-infected controls; and (3) compare the number of rolling and adhered leukocytes between survivors and non-survivors of septic shock.
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