While hypertension has been shown to be a risk factor for vascular dementia, several studies have also demonstrated that hypertension also increases the risk of Alzheimer's disease (AD). Although the relationship between visit-to-visit blood pressure variability (VVV) and cognitive impairment, including AD, have been provided, the mechanisms remain poorly understood. This review paper focuses on the relationship of VVV with AD and summarizes the pathophysiology underlying that relationship, which appears to be mediated by arterial stiffness.
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| http://dx.doi.org/10.3233/JAD-161172 | DOI Listing |
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Comparison of visit-to-visit blood pressure variability and time in target range in predicting risk for cognitive outcomes in the SPRINT trial.
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Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Background: Blood pressure (BP) variability (BPV) and time in target range (TTR) are emerging vascular risk factors for dementia, independent of traditionally targeted mean BP.
Objective: Determine whether BPV or TTR is most strongly associated with cognitive risk.
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From the Rush Institute for Healthy Aging (A.D., K.D., P.D., D.A.E., K.B.R.), and Department of Internal Medicine (A.D., K.D., P.D., D.A.E., K.B.R.), Rush University Medical Center, Chicago, IL; and Department of Neurology (C.S.D., K.B.R.), University of California at Davis, Sacramento.
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- This study explored the connection between blood pressure variability (BPV) and cognitive function in older adults, particularly focusing on those over 65 years old.
- Researchers analyzed data from 4,770 participants from the Chicago Health and Aging Project, measuring blood pressure every three years and assessing cognitive abilities through standardized tests.
- Results indicated that higher BPV was linked to lower cognitive scores, especially among older Black adults, suggesting that fluctuations in blood pressure could contribute to cognitive decline as people age.
Uncover visit-to-visit blood pressure variability as the hidden risk factor/predictor for coronary artery disease, stroke and malignant tumor in patients with type 2 diabetes.
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Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, China.
Visit-to-visit blood pressure variability is a factor for a series of cardiovascular diseases in hypertensive patients. Hypertension is a common complication of patients with type 2 diabetes mellitus. Our research demonstrated that blood pressure variability is more important than systolic blood pressure to be associated with the occurrence of coronary artery disease and stroke.
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Division of Endocrinology and Metabolism, Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, South Korea. Electronic address:
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Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences Tehran, Iran.
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