[Correlations Between - Fusion Gene and Clinical Features of Acute Myeloid Leukemia in Sichuan].

Objectives: To determine the correlations between fusion gene and clinical characteristics of patients with AML,and its association with the prognosis of AML-M2.

Methods: Medical records of 94 AML-M2 cases with positive fusion gene and 51 AML-M2 cases with negative gene were retrospective reviewed.Their clinical characteristics,treatment responses and prognostic outcomes were compared.

Results: No significant differences in the clinical symptoms,predominantly anemia,fever and hemorrhage,were found between the fusion gene positive and negative AML-M2 (>0.05).However,lower levels of red blood cell (RBC) and platelet (PLT),and higher levels of ratio of grain to red,percentage of bone marrow granulocyte (NC),CD34,human leukocyte antigen DR (HLA-DR),CD56 and CD19 were found in those with positive fusion gene (<0.05).The efficacy of treatments and survival curves showed no significant differences between the two groups (>0.05).CD56 and original percentage of bone marrow granulocyte were predictors of poor long-term survival.Complete remission was the only predictor of better long-term survival.

Conclusions: fusion gene is neither associated with clinical symptoms,nor with survival and long term prognosis in Sichuan.As many factors affect the efficacy of treatments and prognosis of AML-M2,stratified analysis is needed to determine the role of .