AI Article Synopsis
- The study aimed to assess how high mobility group N2 protein impacts cervical cancer growth in nude mice.
- The research involved creating a cervical cancer model in nude mice, assigning them to four groups (negative control, HMGN2, cisplatin, and HMGN2 with cisplatin), followed by injections and tumor size measurements.
- Results showed that the negative control group had larger tumor sizes compared to groups treated with HMGN2 and cisplatin, indicating that HMGN2 significantly inhibits tumor growth.
Article Abstract
Objectives: To study the effect of high mobility group chromosomal protein N2 on inhibiting cervical cancer in nude mice.
Methods: Model of cervical cancer were established in nude mice. They were randomly divided into 4 groups including negative control group, HMGN2 group, cisplatin group and HMGN2 with cisplatin group. After 4 injections, the tumor size were calculated and tumor tissues were stained by haematoxylin eosin (HE) staining.
Results: Transplated tumor models were established successfully. The tumor sizes of negative control group [(0.38±0.12) cm³] were significantly lower than those of HMGN2 group [(0.14±0.07)cm³, cisplatin group [(0.11±0.06) cm³] and HMGN2 combined with cisplatin group[(0.11±0.07) cm³]. No differences were detected in HMGN2 group, cisplatin group and HMGN2 with cisplatin group in tumor sizes. The tumor inhibition rates of HMGN2 group, cisplatin group and HMGN2 with cisplatin group were 0.62±0.18, 0.71±0.17 and 0.70±0.18, respectively. The necrosis area were smaller in negative control group than in other three groups by HE staining.
Conclusions: HMGN2 has a significant inhibitory effect on transplanted cervical cancer in nude mice.
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