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"The Razor's Edge of Timing:" A Phenomenological Analysis of Decision-Making Processes Surrounding Medical Aid in Dying.
Int J Public Health
September 2024
Practically Dying, Inc., Longmont, CO, United States.
Objectives: The study aimed to explore how terminally ill individuals in the United States approach medical aid in dying (MAID), including personal, interpersonal and structural factors that influence their decision-making processes.
Methods: This embodied phenomenological study incorporated semi-structured (N = 9) interviews with seven terminally ill adults who received a prescription for MAID. Interviews occurred over Zoom between October 2021-January 2023 and was guided by Ashworth's framework for exploring phenomenological lifeworlds.
On the razor's edge: navigating mature experience and the challenges of aging in modern surgery.
Front Surg
March 2024
Department of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy.
A Razor's Edge: Vascular Responses to Acute Inflammatory Lung Injury/Acute Respiratory Distress Syndrome.
Annu Rev Physiol
February 2024
Center for Inflammation Sciences and Systems Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, Florida, USA; email:
Article Synopsis
- The endothelium, once thought to be a static barrier, is now recognized as a crucial, active tissue that plays a vital role in maintaining the health of organs, particularly in the lungs.
- In healthy individuals, lung endothelial cells (ECs) help maintain balance by promoting processes like vasodilation and reducing inflammation.
- However, under stress from infections or environmental factors, these cells undergo significant changes that contribute to the development of acute respiratory distress syndrome (ARDS), leading to severe inflammation, lung fluid accumulation, and potentially fatal multi-organ dysfunction.
Z-form nucleic acid-binding protein 1 (ZBP1) as a sensor of viral and cellular Z-RNAs: walking the razor's edge.
Curr Opin Immunol
August 2023
Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address:
Z-form nucleic acid-binding protein 1 (ZBP1) detects viral Z-form RNAs (Z-RNAs), activates receptor-interacting protein kinase 3, and triggers cell death during both RNA and DNA virus infections. Such cell death promotes virus clearance by eliminating infected cells and galvanizing antiviral immunity, and is thus often targeted for evasion by virus-encoded suppressors. Recent evidence demonstrates that ZBP1 can also be activated by cellular Z-RNAs transcribed from endogenous retroelements within mammalian genomes.
View Article and Find Full Text PDFThe spread of Carpophilus truncatus is on the razor's edge between an outbreak and a pest invasion.
Sci Rep
November 2022
Institute for Sustainable Plant Protection - IPSP-CNR, National Research Council, P.le E. Fermi, 1, 80055, Portici, NA, Italy.
In 2019, in southern Italy (Campania) there was an outbreak of a sap beetle infesting stored walnut fruits. A monitoring activity started to assess the spread and impact of the pest in walnut orchards and in warehouses, and an integrative characterization led to identify the beetle as Carpophilus truncatus. This species has been in Europe for a long time, rare and harmless until recently.
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