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Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer. | LitMetric

Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer.

EBioMedicine

Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada; Interdisciplinary Oncology Program, University of British Columbia, Vancouver, BC, Canada.

Published: August 2017

AI Article Synopsis

Article Abstract

Emerging evidence indicates that nuclear factor I/B (NFIB), a transcription factor required for proper development and regulation of cellular differentiation in several tissues, also plays critical roles in cancer. Despite being a metastatic driver in small cell lung cancer and melanoma, it has become apparent that NFIB also exhibits tumour suppressive functions in many malignancies. The contradictory contributions of NFIB to both the inhibition and promotion of tumour development and progression, corroborates its diverse and context-dependent roles in many tissues and cell types. Considering the frequent involvement of NFIB in cancer, a better understanding of its multifaceted nature may ultimately benefit the development of novel strategies for the management of a broad spectrum of malignancies. Here we discuss recent findings which bring to light NFIB as a crucial and paradoxical player in cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552107PMC
http://dx.doi.org/10.1016/j.ebiom.2017.05.027DOI Listing

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