AI Article Synopsis
- ATRA is more effective in inhibiting the growth of ER-positive breast cancer cells compared to ER-negative ones, with triple-negative cells like MDA-MB-231 showing poor response.
- The combination of ω-3 free fatty acids and ATRA enhances growth inhibition across various breast cancer subtypes and causes cell cycle arrest.
- This combined treatment triggers cell apoptosis through caspase signaling rather than p53, indicating it may improve the effectiveness of ATRA in breast cancer therapy.
Article Abstract
All-trans retinoic acid (ATRA), one of vitamin A derivatives, shows greater growth inhibition of breast cancer cell for ER-positive than ER-negative cells, while triple negative breast cancer cell such as MDA-MB-231 cell is poorly responsive to ATRA treatment. In this study, we found that combination of ω-3 free fatty acids (ω-3 FFAs) and ATRA exhibited synergistic inhibition of cell growth in three subtypes (ER MCF7, HER2 SK-BR-3, Triple negative HCC1806 and MDA-MB-231 cells) of human breast cancer cell lines. The combined treatment of ω-3 FFAs and ATRA resulted in cell cycle arrest. ω-3 FFAs combined with ATRA synergistically provoked cell apoptosis via the caspase signals but not p53. These findings suggest that combined chemotherapy of ω-3 FFAs with ATRA is beneficial for improvement of ATRA sensitivity in breast cancer cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462805 | PMC |
| http://dx.doi.org/10.1038/s41598-017-03231-9 | DOI Listing |
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