AI Article Synopsis
- Myosin light chain kinase (MLCK) plays a key role in muscle contraction by phosphorylating the myosin light chain, and abnormal MLCK expression is linked to several diseases, including respiratory and cardiovascular disorders, cancer, and inflammatory bowel disease.
- The review discusses signaling pathways that activate MLCK and how this activation can lead to dysfunction in the endothelial barrier, which is crucial for maintaining proper tissue function.
- It also explores the potential benefits of using anti-MLCK agents in treating inflammatory diseases, while highlighting the need to consider possible side effects due to MLCK's widespread presence in various tissues.
Article Abstract
Myosin light chain kinase (MLCK) induces contraction of the perijunctional apical actomyosin ring in response to phosphorylation of the myosin light chain. Abnormal expression of MLCK has been observed in respiratory diseases, pancreatitis, cardiovascular diseases, cancer, and inflammatory bowel disease. The signaling pathways involved in MLCK activation and triggering of endothelial barrier dysfunction are discussed in this review. The pharmacological effects of regulating MLCK expression by inhibitors such as ML-9, ML-7, microbial products, naturally occurring products, and microRNAs are also discussed. The influence of MLCK in inflammatory diseases starts with endothelial barrier dysfunction. The effectiveness of anti-MLCK treatment may depend on alleviation of that primary pathological mechanism. This review summarizes evidence for the potential benefits of anti-MLCK agents in the treatment of inflammatory disease and the importance of avoiding treatment-related side effects, as MLCK is widely expressed in many different tissues.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440522 | PMC |
| http://dx.doi.org/10.3389/fphar.2017.00292 | DOI Listing |
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