In this paper, in order to find novel biologically active pyrazole oximes, a series of pyrazole oxime compounds bearing a substituted pyridyl unit were prepared. Bioassays showed that some target compounds were found to have good acaricidal activity against at a concentration of 500 μg/mL, compound especially displayed potent acaricidal activity against when the concentration was reduced to 100 μg/mL. Interestingly, most target compounds possessed excellent insecticidal activities against at 500 μg/mL. Moreover, some compounds were active against and at 500 μg/mL. Additionally, compounds , , , , , , , , , and displayed significant antiproliferative activities against HepG2 cells with IC values of 1.53-17.27 μM, better than that of the control 5-fluorouracil (IC = 35.67 μM).
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| http://dx.doi.org/10.3390/molecules22060878 | DOI Listing |
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