Elevation of plasma oncostatin M in heart failure.

Aim: Oncostatin M (OSM) is an inflammatory cytokine of the gp130 family. OSM could participate in adverse cardiovascular remodeling through regulation of FGF23.

Materials & Methods: OSM levels were determined in 80 heart failure patients with reduced left ventricular ejection fraction (HFrEF).

Results: OSM levels are significantly increased in HFrEF patients compared with healthy subjects. We have also demonstrated that, in HFrEF patients, plasma OSM levels are correlated to parathyroid hormone PTH(1-84) and 1,25(OH)D, two other biomarkers related to bone and mineral metabolism and associated to adverse cardiovascular outcomes.

Conclusion: OSM concentrations are elevated in HFrEF patients and could interplay with parathyroid hormone and vitamin D impacting cardiovascular function. Nevertheless, the prognostic value of OSM testing appears limited.