Background: Paracoccidioidomycosis (PCM) is a systemic mycosis of acute and chronic evolution, caused by species belonging to the genus Paracoccidioides. It is considered the most prevalent systemic endemic mycosis in Latin America, with cases in the tropical and subtropical regions. Residual PCM refers to the fibrotic scar sequelae resulting from the disease treatment which, when associated with collagen accumulation, leads to functional and anatomic alterations in the organs.
Aims: The aim of this study was to evaluate the vocal function of patients with residual PCM in upper airways and digestive tract.
Methods: We performed a cross-sectional study in 2010 in a cohort of 21 patients with residual PCM in upper airways and digestive tract.
Results: The average age was 49.48±9.1 years, and only two (9.5%) patients were female. The study was performed in the 1-113 month-period (median 27) after the end of drug treatment. Five (23.8%) patients had alterations in the larynx as a sequela of the disease. However, all patients had vocal changes in vocal auditory perceptual analysis by GRBASI scale. The computerized acoustic analysis using the software Vox Metria, showed that 11 patients (52.4%) presented alterations in jitter, 15 (71.4%) in shimmer, 8 (38.1%) in F0, 4 (19%) in glottal to noise excitation (GNE), 7 (33.3%) in the presence of noise and 12 (57.1%) in the presence of vibratory irregularity.
Conclusions: The great frequency of alterations in residual PCM suggests that the patients in such phase could benefit from a multidisciplinary treatment, offering them integral monitoring of the disease, including speech rehabilitation after the PCM is healed.
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http://dx.doi.org/10.1016/j.riam.2017.01.003 | DOI Listing |
Nanomaterials (Basel)
January 2025
State Key Laboratory of Nonferrous Metals and Processes, GRIMN Group Co., Ltd., Beijing 100088, China.
Paraffin wax (PW) has significant potential for spacecraft thermal management, but low thermal conductivity and leakage issues make it no longer sufficient for the requirements of evolving spacecraft thermal control systems. Although free-state expanded graphite (EG) as a thermal conductivity enhancer can ameliorate the above problems, it remains challenging to achieve higher thermal conductivity (K) (>8 W/(m·K)) at filler contents below 10 wt.% and to mitigate the leakage problem.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Chemical Engineering, University of New Brunswick, Fredericton, New Brunswick E3B5A3, Canada.
The practical application of polyethylene glycol (PEG) phase change materials (PCMs) necessitates exceptional shape stability, rapid thermal responsiveness, and a substantial thermal storage capacity. The present study focuses on the fabrication of a highly robust cellulose nanofibril (CNF) based aerogel with an ordered structure, serving as a three-dimensional (3D) scaffold for PEG to effectively prevent any potential leakage. Additionally, hydroxyl and amino functional groups are introduced to functionalize boron nitride nanosheets (BNNS-g), which are incorporated into the aerogel to enhance its thermal conductivity.
View Article and Find Full Text PDFWater Res
December 2024
Department of Civil and Environmental Engineering Sciences, Institute IWAR, Chair of Water and Environmental Biotechnology, Technical University of Darmstadt, Germany. Electronic address:
Organic micropollutants (OMP) are ubiquitous in aquatic ecosystems and have a proven negative impact on the environment and drinking water resources. To remove OMP from municipal wastewater, the use of superfine Powdered Activated Carbon (sPAC) (d = 1.0 µm) compared to Powdered Activated Carbon (PAC) (d = 30.
View Article and Find Full Text PDFBMC Public Health
November 2024
INSERM, Université de Nantes - Université de Tours, UMR U1246 SPHERE, Methods in patient- centered outcomes and health research, Nantes, France.
Background: To examine the psychometrics properties of the French version of two scales measuring general (HLS-Q12) and navigational (HLS-NAV) health literacy (HL) using validation methods based on modern psychometric test theories: a Rasch model analysis.
Methods: The data on representative samples of the French adult population came from the Health Literacy Survey (N = 2 003), conducted in France in two waves (2020 and 2021), and from the third wave of SLAVACO study (N = 2 022), conducted in December 2021. A Rasch analysis was performed using a partial credit model with marginal maximum likelihood estimation adapted to polytomous data.
Breast Cancer Res Treat
October 2024
The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
Purpose: Detection of molecular residual disease (MRD) allows for the identification of breast cancer patients at high-risk of recurrence, with the potential that early initiation of treatment at early stages of relapse could improve patient outcomes. The Invitae Personalized Cancer Monitoring™ assay (PCM) is a newly developed next-generation sequencing approach that utilizes up to 50 patient-specific, tumor-informed DNA variants, to detect circulating tumor DNA (ctDNA). The ability of the PCM assay to detect MRD before clinical relapse was evaluated.
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