A novel and efficient method for the synthesis of (Z)-fluorinated alkenylboronic acid pinacol esters via Cu-catalyzed stereoselective borylation of gem-difluoroalkenes using bis(pinacolato)diboron (Bpin) as the boron source with the assistance of NaOtBu and Xantphos at room temperature was developed.
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| http://dx.doi.org/10.1021/acs.orglett.7b01430 | DOI Listing |
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