Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1136/vr.116.3.74 | DOI Listing |
Cell Commun Signal
January 2025
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Background: Cryptorchidism is the absence of one or both testicles in the scrotum at birth, being a risk factor for testis cancer and infertility. The most effective method to treat cryptorchidism is orchiopexy, followed by human chorionic gonadotropin (hCG) therapy; however, a portion of treated patients do not show a significant improvement in testis volume and vascularization after adjuvant therapy.
Methods: In this study, we generated an in vitro model to predict the patient response to hCG by cultivating and treating primary cells derived from five cryptorchid patients' biopsies of gubernaculum testis, the ligament that connects the testicle to the scrotum.
Genome Biol Evol
December 2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, Guangdong, China.
Protamines (PRMs) and transition nuclear proteins (TNPs) are two key classes of sperm nuclear basic proteins that regulate chromatin reorganization and condensation in the spermatozoon head, playing crucial roles in mammalian spermatogenesis. In scrotal mammals, such as humans, cryptorchidism, the failure of the testes to descend into the scrotal sac is generally associated with higher rates of defective spermatozoon quality and function. However, ascrotal mammals, such as cetaceans, with naturally undescended testes, produce normal spermatozoa similar to their scrotal counterparts.
View Article and Find Full Text PDFJ Clin Med
November 2024
Pediatric Endocrinology Department, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
Male patients with congenital hypogonadotropic hypogonadism (CHH) have impaired postnatal activation of the hypothalamic-pituitary-gonadal axis that occurs during mini-puberty. The aim of this study was to report our experience using gonadotropin replacement therapy for mini-puberty in male infants with CHH and to establish treatment recommendations. The patients included in this retrospective case series ( = 9) were diagnosed in the postnatal period due to micropenis, with two being accompanied by cryptorchidism and four with other associated hormonal deficits.
View Article and Find Full Text PDFHum Reprod
October 2024
Center for Medical Genetics Ghent, Ghent University Hospital, Ghent, Belgium.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!