AI Article Synopsis
- The study aimed to compare the clinicoradiologic features of HPV-positive and HPV-negative oropharyngeal carcinoma, analyzing data from tumors between 2008 and 2013.
- HPV-positive tumors exhibited more exophytic growth, well-defined borders, smaller sizes, and greater lymph node involvement with cystic appearances compared to HPV-negative tumors.
- Nomograms were developed using clinical and radiologic features to assess the likelihood of a tumor being HPV-driven, showing a good predictive accuracy (AUC = 0.84).
Article Abstract
Background: The purpose of this study was to compare the clinicoradiologic characteristics of human papillomavirus (HPV)-related (HPV-positive) and HPV-unrelated (HPV-negative) oropharyngeal carcinoma (OPC).
Methods: Primary tumor and lymph node features of HPV-positive and HPV-negative OPCs from 2008 to 2013 were compared on pretreatment CT/MRI. Intrarater/interrater concordance was assessed. Multivariable analyses identified factors associated with HPV-positivity to be used in nomogram construction.
Results: Compared to HPV-negative (n = 194), HPV-positive (n = 488) tumors were more exophytic (73% vs 63%; p = .02) with well-defined border (58% vs 47%; p = .033) and smaller axial dimensions; lymph node involvement predominated (89% vs 69%; p < .001) with cystic appearance (45% vs 32%; p = .009) but similar topography. Intrarater/interrater concordance varied (fair to excellent). Nomograms combining clinical (age, sex, smoking pack-years, subsite, T/N classification) and/or radiologic (nonnecrotic tumor and cystic lymph node) features were used to weigh the likelihood of HPV-driven tumors (area under the curve [AUC] = 0.84).
Conclusion: HPV-positive OPC has different radiologic tumor (exophytic/well-defined border/smaller axial dimension) and lymph node (cystic) features but similar lymph node topography.
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| http://dx.doi.org/10.1002/hed.24764 | DOI Listing |
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