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Pneumolysin Is Responsible for Differential Gene Expression and Modifications in the Epigenetic Landscape of Primary Monocyte Derived Macrophages.
Front Immunol
June 2021
MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.
Epigenetic modifications regulate gene expression in the host response to a diverse range of pathogens. The extent and consequences of epigenetic modification during macrophage responses to , and the role of pneumolysin, a key virulence factor, in influencing these responses, are currently unknown. To investigate this, we infected human monocyte derived macrophages (MDMs) with and addressed whether pneumolysin altered the epigenetic landscape and the associated acute macrophage transcriptional response using a combined transcriptomic and proteomic approach.
View Article and Find Full Text PDFPlatelets as Central Actors in Thrombosis-Reprising an Old Role and Defining a New Character.
Semin Thromb Hemost
November 2019
Atherothrombosis and Vascular Biology Program, Baker Heart and Diabetes Institute, Melbourne, Australia.
Platelets have long been considered simple anucleate cells that rapidly adhere and aggregate at sites of vascular injury. However, recent in vivo experimental data have shed new light on the platelet response to vascular injury. These data have unexpectedly revealed that platelet thrombus formation is a highly dynamic process and yields a platelet thrombus with a distinct hierarchical structure composed of a "core" of highly activated platelets and a "shell" of platelets in a low activation state.
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World Health Organization, Geneva, Switzerland.
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