Proton dissociation properties of arylphosphonates: Determination of accurate Hammett equation parameters.

Determination of the proton dissociation constants of several arylphosphonic acid derivatives was carried out to investigate the accuracy of the Hammett equations available for this family of compounds. For the measurement of the pK values modern, accurate methods, such as the differential potentiometric titration and NMR-pH titration were used. We found our results significantly different from the pK values reported before (pK: MAE = 0.16 pK: MAE=0.59). Based on our recently measured pK values, refined Hammett equations were determined that might be used for predicting highly accurate ionization constants of newly synthesized compounds (pK=1.70-0.894σ, pK=6.92-0.934σ).