AI Article Synopsis
- Gastroenterology guidelines suggest using endoscopic surveillance to find early-stage cancer in Barrett's esophagus, but cases of esophageal adenocarcinoma are still rising in Western countries, indicating the method might not be effective enough.
- Current techniques depend heavily on the endoscopist's skill in spotting questionable areas for biopsies, as well as random biopsies and pathology results.
- The review discusses the difficulties in using dysplasia to determine cancer risk and explores the potential of molecular biomarkers and in vivo imaging to better detect early cancer in Barrett's esophagus.
Article Abstract
Gastroenterology society guidelines recommend endoscopic surveillance as a means to detect early stage cancer in Barrett's esophagus. However, the incidence of esophageal adenocarcinoma in Western countries continues to increase, suggesting that this strategy may be inadequate. Current surveillance methods rely on the endoscopist's ability to identify suspicious areas of Barrett's esophagus to biopsy, random biopsies, and on the histopathologic diagnosis of dysplasia. This review highlights the challenges of using dysplasia to stratify cancer risk and addresses the development and use of molecular biomarkers and in vivo molecular imaging to detect early neoplasia in Barrett's esophagus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458534 | PMC |
| http://dx.doi.org/10.1016/j.giec.2017.02.003 | DOI Listing |
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