Forward thinking does not seek to predict the future, to unveil it as if it were already in existence, rather, its aim is to help us to construct it. Although today's epidemiological and therapeutic situations for urogenital tumours can evolve over the next 10 years, diagnostic and therapeutic methods, as well as the treatment and implementation of innovations, are already rapidly changing. Rather than reducing our prospective thinking to the therapeutic treatment of cancer only, we will aim at proposing a global sanitary vision that includes diagnosis, therapies, prevention, routine utilisation of technomedicine, genomics and even nanomedicine. This journey into the near future of tomorrow's cancerology holds the promise of being better adapted to the evolution of the medical thinking process. Imagining the way we will be treating renal, prostatic and urothelial tumours in 10 years' time is as much an introspection into our present day treatment system as a projection into its hoped for future evolution.
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http://dx.doi.org/10.1016/j.nephro.2017.01.013 | DOI Listing |
Int J Biol Macromol
January 2025
School of Basic Medicine, Qingdao University, Qingdao 266071, China. Electronic address:
Fructose-1,6-bisphosphatase 1 (FBP1) is a key gluconeogenic enzyme that plays complex and context-dependent roles in cancer biology. This review comprehensively examines FBP1's dual functions as both a tumor suppressor and an oncogene across various cancer types. In many cancers, such as hepatocellular carcinoma, clear cell renal cell carcinoma, and lung cancer, downregulation of FBP1 contributes to tumor progression through metabolic reprogramming, promoting glycolysis, and altering the tumor microenvironment.
View Article and Find Full Text PDFAdv Urol
December 2024
Departments of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, Japan.
Since contact laser vaporization of the prostate (CVP) was approved by the Japanese insurance system in 2016, the use of a 980 nm diode laser system for CVP has become widespread for treating benign prostate hyperplasia (BPH) patients. Our institute has been implementing CVP for BPH since 2018, treating a total of 93 patients, including 28 with a risk of hemorrhage. This study examines the safety and efficacy of CVP treatment for BPH patients with a hemorrhagic risk.
View Article and Find Full Text PDFProstate
December 2024
Department of Neurosciences and Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
Background: This study aims to assess the relationship between body mass index (BMI) and prostate volume, utilizing pre and postoperative measurements.
Methods: A retrospective, observational study was conducted at a single site using data from an institutional database. Medical records of patients who underwent robot-assisted radical prostatectomy were reviewed.
Ultrasonography
December 2024
Professor Emeritus, Department of Radiology, Seoul National University Hospital, Seoul, Korea.
Nutcracker syndrome is caused by the compression of the left renal vein between the abdominal aorta and the superior mesenteric artery. The use of Doppler ultrasonography to diagnose this condition is challenging due to the dynamic nature of the nutcracker phenomenon and the variability of its symptoms, which can fluctuate with changes in patient posture and respiration. This review emphasizes the critical role of Doppler ultrasonography in identifying and managing nutcracker syndrome.
View Article and Find Full Text PDFCureus
November 2024
Urology, Division of Clinical Surgical Sciences, University of the West Indies, Saint Augustine, TTO.
Chronic bacterial prostatitis is generally difficult to treat. It may involve multiple courses of antibiotics and may be difficult to eradicate with high rates of recurrence. We present the case of a 33-year-old male patient with a previous history of renal tract calculi, stent insertions, and perinephric abscess with percutaneous drainage, which then led to a right nephrectomy.
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