Zetidoline (ZET), a rather selective dopamine (DA) D2-receptor blocker, was found to be equipotent to haloperidol and over 300 times as potent as sulpiride in activating the firing rate of substantia nigra dopaminergic neurons (SN-DA neurons) in unanesthetized rats. Moreover, like classic and atypical neuroleptics, ZET reversed and prevented apomorphine-induced inhibition of SN-DA neurons.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0024-3205(85)90258-9 | DOI Listing |
Publication Analysis
Top Keywords
dopaminergic neurons
8
sn-da neurons
8
zetidoline novel
4
novel neuroleptic
4
neuroleptic activates
4
activates nigral
4
nigral dopaminergic
4
neurons
4
neurons rats
4
rats zetidoline
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!