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Visualization of human helper T lymphocyte differentiation antigen in primate brain.
Peptides
June 1993
Laboratory of Molecular Immunoregulation, NCI-Frederick Cancer Research Facility, MD 21701-1240.
The differentiation antigen T4 is present on the helper/inducer subset of T cells. In the acquired immune deficiency syndrome (AIDS), this lymphocyte subset is selectively depleted by HTLV-III/LAV virus which apparently uses the T4 antigen as a viral receptor. The autoradiographic visualization of the T4 antigen on sections of squirrel monkey brain shown here reveals a heterogeneous pattern with clustering in the same emotion-mediating regions of the brain that are usually enriched with neuropeptide receptors.
View Article and Find Full Text PDFIn a study of genetic variation in the AIDS virus, HTLV-III/LAV, sequential virus isolates from persistently infected individuals were examined by Southern blot genomic analysis, molecular cloning, and nucleotide sequencing. Four to six virus isolates were obtained from each of three individuals over a 1-year or 2-year period. Changes were detected throughout the viral genomes and consisted of isolated and clustered nucleotide point mutations as well as short deletions or insertions.
View Article and Find Full Text PDFTo determine the extent and nature of genetic variation present in independent isolates of HTLV-III/LAV, the nucleotide sequences of the entire envelope gene and parts of gag and pol were determined for two AIDS viruses. The results indicated that variation throughout the viral genome is extensive and that the envelope gene in particular is most highly variable. Within the envelope, changes were most prevalent within the extracellular region where clustered nucleotide substitutions and deletions/insertions were evident.
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