COMPLEX HEAVY METAL SALTS' EFFECT ON GANGLION NUCLEI NEURONS MORPHOLOGICAL FUNCTIONS IN ADULT MALE RATS' CEREBELLAR CORTEX.

In order to analyze the dynamics of morphological and morphometric nuclear rearrangements of cortical cerebellar Purkinje cells under prolonged exposure (for 90 days) on the body of copper sulfate, zinc and iron experiment was conducted on 48 white adult male rats weighing 200-250g, aged 5 -8 months. We used anatomic, morphometric, statistical and common methods of micro anatomical research method. It was found that the combined effect of copper sulfate, zinc and iron on the body has nuclear device ganglion neurons in the cerebellar cortex sufficiently expressive toxicity, which affects the state of neurons. The degree of morphological rearrangements in the nuclear unit is in direct proportion to the duration of the experiment. In the nuclei of ganglion neurons develop nonspecific changes of polymorphic nature, which is reversible in the early stages of experience and irreversible, mainly necrobiotic character (chromatolysis, pycnosis and reksis) in most of the neurons within a timeline.