AI Article Synopsis
- The study aimed to identify the signaling molecules involved in the formation of advanced glycation end-products (AGEs) in the brains of rats exposed to cadmium chloride and to assess the effects of camel whey proteins and extracts.
- Ninety male rats were divided into five groups, with one serving as a control and the others given cadmium chloride to induce neurodegeneration, while some received daily treatments of whey protein, extract, or both for 12 weeks.
- Results showed that the combination of whey protein and extract significantly reduced AGEs and inflammatory markers, suggesting their potential in preventing neuropathy progression more effectively than individual treatments.
Article Abstract
Background: The goal of this study was identification signaling molecules mediated the formation of AGEs in brain of rats injected with CdCl2 and the role of camel whey proteins and extract on formation of AGEs in brain.
Methods: Ninety male rats were randomly grouped into five groups; Normal control (GpI) and the other rats (groups II-V) were received a single dose of cadmium chloride (5 μg/kg/b.w) for induction of neurodegeneration. Rats in groups III-V were treated daily with whey protein (1g/kg b.w) or extract (1mg/kg b.w) or combined respectively for 12 weeks.
Results: It was found that whey protein combined with extract prevented the formation of AGEs and enhance the antioxidant activity compared with untreated group (p <0.001). Serum tumor necrosis factor (TNF-α) and interleukine (IL-6) levels were significantly decreased (p<0.01) in rats treated with whey protein and extract formation compared with untreated. The combined treatment showed a better impact than individual ones (p<0.001). The level of cAMP but not cGMP were lowered in combined treatment than individual (p<0.01).
Conclusion: It can be postulated that Whey protein + extract formation could have potential benefits in the prevention of the onset and progression of neuropathy in patients.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446448 | PMC |
| http://dx.doi.org/10.21010/ajtcam.v14i2.25 | DOI Listing |
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