AI Article Synopsis
- Severe acute pancreatitis (SAP) and obstructive jaundice (OJ) are serious health issues, and Salviae miltiorrhizae has shown potential in protecting organs in related animal models, though the mechanisms are still unclear.
- This study involved 288 rats to investigate the effects of Salviae miltiorrhizae injection on kidney function, focusing on factors like mortality rates, kidney-related serum markers and apoptosis-related proteins.
- Results indicated that treatment with Salvia miltiorrhizae led to significant improvements in kidney health, as evidenced by lower serum creatinine levels and reduced apoptosis in treated rats compared to control groups.
Article Abstract
Background: Severe acute pancreatitis (SAP) and obstructive jaundice (OJ) are frequent recurring diseases that bring about huge threat to human health. Some reports have demonstrated that Salviae miltiorrhizae can protect multiple organs of SAP and OJ model animals or patients, but their related mechanisms were not clear. In this study, we observed the effects of Salvia miltiorrhizae injection on apoptosis and NF-κB expression in kidney and explored the protective effect and mechanism of Salvia miltiorrhizae on the kidney of SAP or OJ rats. The results obtained will provide a theoretical basis for clinical application of Salvia miltiorrhizae.
Material And Methods: A total of 288 rats were used for SAP -and OJ-associated experiments. The mortality rates of rats, the contents of serum BUN and CREA, the expression levels of Bax, NF-κB proteins and the apoptosis index were observed, respectively.
Results: The pathological changes in the kidney of SAP or OJ rats in treated group were mitigated to varying degrees. At 6 and 12 hours after operation in SAP rats or on 21 and 28 days after operation in OJ rats, the contents of serum CREA in treated group were significantly lower than those in model control group; At 3 and 6 hours after operation, the staining intensity of Bax protein of kidney in treated group was significantly lower than that in model control group; on 14 days after operation, the apoptosis index in the kidney of OJ rats in treated group was significantly lower than that in model control group.
Conclusion: Salvia miltiorrhizae can exert protective effects on the kidney of SAP and OJ rats.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446434 | PMC |
| http://dx.doi.org/10.21010/ajtcam.v14i2.12 | DOI Listing |
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