AI Article Synopsis
- The use of glycine distension solution in surgeries like transurethral prostatectomy (TURP) and hysteroscopy can lead to serious complications, including death, due to its toxic effects on the brain and the resulting hyperammonemia.
- Researchers propose that brain edema and mortality may actually be due to osmotic brain edema, caused by glycine selectively diffusing into the brain while sodium remains trapped inside due to the lack of sodium transporters in cerebral capillaries.
- This hypothesis explains the unidirectional diffusion of solutes into the brain during glycine-associated hyponatremia, challenging the previous understanding that the condition is non-toxic.
Article Abstract
Death following the use the glycine distension solution in transurethral prostatectomy (TURP) or hysteroscopic surgery has been attributed to the toxic effect of glycine on the brain through the glycine receptors and hyperammonemia, contending that glycine-associated hyponatremia is isosmotic and therefore would not cause brain oedema. Here we propose a hypothesis that the mechanism of brain oedema and death is actually osmotic brain oedema caused by selective diffusion of glycine into the brain while sodium cannot diffuse out of the brain despite favourable concentration gradient because of the absence of sodium transporter on the cerebral capillaries needed for the exit of sodium from the brain. The mechanism for unidirectional diffusion of solutes into the brain in glycine-associated hyponatremia is explained.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.mehy.2017.03.035 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!