Channelopathies comprise various diseases caused by defects of ion channels. Modifications of their biophysical properties are common and have been widely studied. However, ion channels are heterogeneous multi-molecular complexes that are extensively modulated and undergo a maturation process comprising numerous steps of structural modifications and intracellular trafficking. Perturbations of these processes can give rise to aberrant channels that cause pathologies. Here we review channelopathies of the nervous system associated with dysfunctions at the post-translational level (folding, trafficking, degradation, subcellular localization, interactions with associated proteins and structural post-translational modifications). We briefly outline the physiology of ion channels' maturation and discuss examples of defective mechanisms, focusing in particular on voltage-gated sodium channels, which are implicated in numerous neurological disorders. We also shortly introduce possible strategies to develop therapeutic approaches that target these processes. This article is part of the Special Issue entitled 'Channelopathies.'
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neuropharm.2017.05.028 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Calcium Ions in the Physiology and Pathology of the Central Nervous System.
Int J Mol Sci
December 2024
Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Calcium ions play a key role in the physiological processes of the central nervous system. The intracellular calcium signal, in nerve cells, is part of the neurotransmission mechanism. They are responsible for stabilizing membrane potential and controlling the excitability of neurons.
View Article and Find Full Text PDFExploring Cardiac Sympathetic Denervation as a Treatment Approach for Recurrent Ventricular Arrhythmias: A Concise Review.
J Clin Exp Cardiolog
March 2024
Division of Thoracic Surgery, Johns Hopkins University School of Medicine, Baltimore, USA.
Article Synopsis
- * Bilateral CSD (BCSD) shows an approximate 60% reduction in implantable cardioverter defibrillator shocks and over 50% one-year survival without shock or transplant, while the 2017 guidelines endorse the left CSD for specific RVT types.
- * Despite the promising results, many studies have small sample sizes leading to potential underreporting of complications; more research is needed to fully understand the long
Patterns, delays, and associated factors of help-seeking behaviour for lifetime mood disorders and anxiety disorders: A national representative survey.
J Affect Disord
December 2024
The Affiliated Brain Hospital, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou 510370, China. Electronic address:
Article Synopsis
- Utilisation of health services for mood and anxiety disorders in China is low and often delayed, despite the availability of effective treatments.
- The study analyzed data from the China Mental Health Survey, identifying 3,075 patients out of 32,552 surveyed, with only 15.5% seeking any health care, and even fewer (4.8%) pursuing specialized mental health services.
- Key findings indicated that delays in seeking care were significant, particularly for depressive (1.0 years), bipolar (1.9 years), and anxiety disorders (10.0 years), with younger patients and those with comorbidities more likely to seek help.
- The study suggests that national strategies are essential for increasing health care utilization among individuals with mental health
Small fiber neuropathy.
Int Rev Neurobiol
November 2024
Department of Neurology, Mental Health and Neuroscience Research Institute, Maastricht University Medical Center+, Maastricht, Netherlands.
Small fiber neuropathy (SFN) is a condition involving the small nerve fibers of the peripheral nervous system, specifically the thinly myelinated Aδ and unmyelinated C fibers. It is an increasingly acknowledged condition within the spectrum of neuropathic pain disorders, leading to a rise in diagnosed patients. SFN is characterized by neuropathic pain, that is often described as burning, and typically presents in the hands and feet ascending proximally.
View Article and Find Full Text PDFA longitudinal network of psychotic-like experiences, depressive and anxiety symptoms, and adverse life events: a cohort study of 3,358 college students.
Epidemiol Psychiatr Sci
November 2024
Department of Social Psychiatry, the Affiliated Brain Hospital, Guangzhou Medical University, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China.
Aims: Psychotic-like experiences (PLEs), especially for persistent PLEs, are highly predictive of subsequent mental health problems. Hence, it is crucial to explore the psychopathological associations underlying the occurrence and persistence of PLEs. This study aimed to explore the above issues through a longitudinal dynamic network approach among PLEs and psychological and psychosocial factors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!