AI Article Synopsis
- This study explores cognitive impairment in survivors of intracerebral hemorrhage (ICH), particularly focusing on those with cerebral amyloid angiopathy (CAA) and comparing them to patients with mild cognitive impairment from Alzheimer's disease (MCI-AD) and healthy individuals.
- Researchers assessed 20 patients from each group using neuropsychological tests and MRI scans, revealing that a significant majority of ICH patients exhibited mild cognitive disorders.
- The results showed no cognitive differences between CAA-related and deep ICH patients, but specific cognitive impairments, especially in naming and processing speed, were highlighted as distinct from those observed in Alzheimer's patients.
Article Abstract
Background: Cognitive impairment seems to be frequent in intracerebral hemorrhage (ICH) survivors, but remains widely understudied. In this study, we investigated the frequency and patterns of vascular cognitive disorders (VCDs) in patients with cerebral amyloid angiopathy (CAA)-related and deep ICH compared to patients with mild cognitive impairment due to Alzheimer's disease (MCI-AD) and healthy controls.
Methods: We prospectively recruited 20 patients with CAA-related lobar ICH, 20 with deep ICH, 20 with MCI-AD and 17 healthy controls. Patients with cognitive decline pre-ICH were excluded from the analysis. Each participant underwent a comprehensive neuropsychological assessment and a structural brain MRI. Cognitive assessment was performed at a median delay of 4 months after the acute phase in ICH patients, and more than 6 months after the first complaint in MCI-AD patients. Cognitive profiles were compared between groups. The prevalence of VCDs in the ICH groups was estimated using the recent VASCOG criteria.
Results: "Mild" and "major VCDs" were respectively observed in 87.5% and 2.5% of all ICH patients. Every patient in the CAA group had mild VCDs. No significant difference was observed in cognitive functioning between CAA-related and deep ICH patients. The most impaired process in the CAA group was naming, with a mean (±standard deviation) z-score of -5.2 ±5.5, followed by processing speed (-4.1±3.3), executive functioning (-2.6 ±2.5), memory (-2.4 ±3.5) and attention (-0.9 ±1.3). This cognitive pattern was different from the MCI-AD patients, but the groups were only different in gestural praxis, and by construction, in memory processes.
Conclusions: VCDs are frequent after ICH. Cognitive patterns of patients with deep or CAA-related ICH did not differ, but there was impaired performance in specific domains distinct from the effects of Alzheimer's disease.
Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01619709.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453588 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178886 | PLOS |
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