We investigate how the mental lexicon changes over the life span using free association data from over 8,000 individuals, ranging from 10 to 84 years of age, with more than 400 cue words per age group. Using network analysis, with words as nodes and edges defined by the strength of shared associations, we find that associative networks evolve in a nonlinear (U-shaped) fashion over the life span. During early life, the network converges and becomes increasingly structured, with reductions in average path length, entropy, clustering coefficient, and small world index. Into late life, the pattern reverses but shows clear differences from early life. The pattern is independent of the increasing number of word types produced per cue across the life span, consistent with a network encoding an increasing number of relations between words as individuals age. Lifetime variability is dominantly driven by associative change in the least well-connected words. (PsycINFO Database Record
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Brief Bioinform
November 2024
Department of Computer Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong, 999077, China.
The complexity of T cell receptor (TCR) sequences, particularly within the complementarity-determining region 3 (CDR3), requires efficient embedding methods for applying machine learning to immunology. While various TCR CDR3 embedding strategies have been proposed, the absence of their systematic evaluations created perplexity in the community. Here, we extracted CDR3 embedding models from 19 existing methods and benchmarked these models with four curated datasets by accessing their impact on the performance of TCR downstream tasks, including TCR-epitope binding affinity prediction, epitope-specific TCR identification, TCR clustering, and visualization analysis.
View Article and Find Full Text PDFPsychol Aging
February 2025
Wilhelm Wundt Institute of Psychology, Leipzig University.
In this editorial, I outline two key changes to the submission guidelines, and I present my vision as the new editor for Psychology and Aging, the premier outlet for psychological research on aging and adult lifespan development. To enhance the impact of research published in the journal, my editorial team and I will accept articles that make strong theoretical contributions, are methodologically rigorous and transparent, use open science practices, contribute cumulative knowledge to the field, and have important practical implications. We will continue to publish high-quality empirical articles, systematic reviews, and meta-analyses, as well as theory development and methodological articles from all areas of psychology and related disciplines that focus on basic principles of aging and adult lifespan development or that investigate these principles in applied settings.
View Article and Find Full Text PDFBull Math Biol
January 2025
School of Mathematics and Statistics, The University of Sydney, Sydney, NSW, 2006, Australia.
Compared to our closest primate relatives, human life history involves greater longevity, which includes a distinctive postmenopausal life stage. Given mammalian reproductive physiology in which females build a finite stock of cells that can become oocytes early in life, which then continuously deplete mostly through cell death while males produce new sperm throughout adulthood, the postmenopausal stage makes the sex ratio in the fertile pool, called the adult sex ratio (ASR), male biased. Additionally, this affects a more fine-grained ratio, the operational sex ratio (OSR), defined as the ratio of males to females currently able to conceive.
View Article and Find Full Text PDFDis Colon Rectum
January 2025
Department of Surgery, Division of Colorectal Surgery, The Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Background: Minimally invasive ventral rectopexy has widely become the preferred prolapse procedure. However there have been recent concerns regarding the safety of permanent synthetic mesh in the pelvis. Biologic grafts have also been commonly used as an alternative prosthesis, but data on their safety and the longevity of the prolapse repair have been lacking.
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