Cytomegalovirus, Macrophages and Breast Cancer.

Open Virol J

Pathogens & Inflammation/EPILAB Laboratory, Department of Virology, University of Franche-Comté, COMUE Bourgogne Franche-Comté University, UPRES EA4266, SFR FED 4234, CHRU Besançon, Besançon, France.

Published: March 2017

The human cytomegalovirus (HCMV) is a betaherpesvirus that is highly host specific, infects among others epithelial cells and macrophages, and has been recently mentioned as having oncomodulatory properties. HCMV is detected in the breast tumor tissue where macrophages, especially tumor associated macrophages, are associated with a poor prognosis. In this review, we will discuss the potential implication of HCMV in breast cancer with emphasis on the role played by macrophages.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420183PMC
http://dx.doi.org/10.2174/1874357901711010015DOI Listing

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