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Oral cannabidiol did not impair learning and memory in healthy adults.
J Cannabis Res
January 2025
Department of Biology, Colorado State University Pueblo, 2200 Bonforte Blvd, Pueblo, CO, 81001, USA.
Background: The effect of oral Cannabidiol (CBD) on interference during learning and memory (L&M) in healthy human volunteers has not been studied.
Method: A two-arm crossover, randomized, double-blind, placebo-controlled trial was conducted at Colorado State University Pueblo (CSU Pueblo) to evaluate the effects of 246 mg oral CBD on L&M in healthy adults. Among 57 healthy volunteers enrolled, 35 were included in the analyses.
Conditioning a collective avoidance response in rummy-nose tetra.
J Fish Biol
January 2025
Centre de Recherches sur la Cognition Animale, Centre de Biologie Intégrative (CBI), Centre National de la Recherche Scientifique (CNRS) & Université de Toulouse (UPS), Toulouse, France.
Escape waves in animal groups, such as bird flocks and fish schools, have attracted a lot of attention, as they provide the opportunity to better understand how information can efficiently propagate in moving groups, and how individuals can coordinate their actions under the threat of predators. There is a lack of appropriate experimental protocols to study escape waves in highly social fish, in which the number of individuals initiating the escape and the identity of the initiators are controlled. Indeed, highly social fish or obligate schoolers have a tendency to not respond well or to freeze when tested in experimental setups designed for single individuals.
View Article and Find Full Text PDFMAGPIE: A Machine Learning Approach to Decipher Protein-Protein Interactions in Human Plasma.
J Proteome Res
January 2025
Department of Biochemistry, Microbiology and Immunology and Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada.
Immunoprecipitation coupled to tandem mass spectrometry (IP-MS/MS) methods are often used to identify protein-protein interactions (PPIs). While these approaches are prone to false positive identifications through contamination and antibody nonspecific binding, their results can be filtered using negative controls and computational modeling. However, such filtering does not effectively detect false-positive interactions when IP-MS/MS is performed on human plasma samples.
View Article and Find Full Text PDFPotential influence of different peri-operative analgesic regimens on tumour biology and outcome after oncologic surgery: A narrative review.
Eur J Anaesthesiol
March 2025
From the Département d'Anesthésie, Chirurgie et Interventionnel (LB), U1138 Metabolism, Cancer and Immunity, Gustave Roussy, Villejuif, France (LB), Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, California, USA (LB), Aberdeen Centre for Arthritis and Musculoskeletal Health (Epidemiology Group), Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition (PF), Anaesthesia department, NHS Grampian, Aberdeen, UK (PF), IMAGINE UR UM 103, Montpellier University, Anesthesia Critical Care, Emergency and Pain Medicine Division, Nîmes University Hospital, Nîmes, France (PF), Pain and Opioids after Surgery (PANDOS) European Society of Anaesthesiology and Intensive Care (ID ESAIC_RG_PAND) Research Group, Brussels, Belgium (PF), Department of Anaesthesiology, Amsterdam UMC, Amsterdam, The Netherlands (MWH), School of Pharmacy, The University of Queensland, Pharmacy Australia Centre of Excellence, Woolloongabba Qld, Australia (M-OP), Department of Anaesthesiology and Intensive Care, University of Leipzig Medical Center, Leipzig, Germany (TP), EuroPeriscope, ESAIC Onco-Anaesthesiology Research Group, Brussels, Belgium (TP, LB, PF, MWH).
The management of peri-operative pain is one of the pillars of anaesthesia and is of particular importance in patients undergoing surgery for solid malignant tumours. Amongst several options, the most commonly employed analgesic regimens involve opioids, NSAIDs and regional anaesthesia techniques with different local anaesthetics. In recent years, several research reports have tried to establish a connection between peri-operative anaesthesia care and outcome after cancer surgery.
View Article and Find Full Text PDFMulti-Night Electroencephalography Reveals Positive Association Between Sleep Efficiency and Hippocampal Subfield and Entorhinal Cortex Volumes in Healthy Aging.
Hum Brain Mapp
December 2024
Brain Imaging Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.
Age-related atrophy of the human hippocampus and the enthorinal cortex starts accelerating at around age 60. Due to the contributions of these regions to many cognitive functions seamlessly used in everyday life, this can heavily impact the lives of elderly people. The hippocampus is not a unitary structure, and mechanisms of its age-related decline appear to differentially affect its subfields.
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