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GITRL enhances cytotoxicity and persistence of CAR-T cells in cancer therapy.
Mol Ther
January 2025
Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, China, 200241. Electronic address:
CAR T-cell therapy has achieved remarkable clinical success in treating hematological malignancies. However, its clinical efficacy in solid tumors is less satisfactory, partially due to poor in vivo expansion and limited persistence of CAR-T cells. Here, we demonstrated that the overexpression of glucocorticoid-induced tumor necrosis factor receptor-related protein ligand (GITRL) enhances the anti-tumor activity of CAR-T cells.
View Article and Find Full Text PDFLong-Term Clinical Outcomes of Transalveolar Maxillary Sinus Floor Elevation with Rotatory Instruments: An 8-Year Follow-Up Prospective Clinical Study.
J Clin Med
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Comprehensive Dentistry for Adults and Gerodontology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain.
Transalveolar sinus floor elevation (TSFE) is a surgical technique for the placement of dental implants in patients with reduced height of the maxillary posterior alveolar bone. This study aims to demonstrate the clinical outcomes of TSFE using the minimal invasive sinus elevation (MISE) technique in partially and totally edentulous maxillary patients. This prospective clinical study followed STROBE guidelines.
View Article and Find Full Text PDFSandwiched Strut Allografts with Stem Retention to Treat Fragile Periprosthetic Femoral Fractures: A Case Report.
Medicina (Kaunas)
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Department of Orthopaedic Surgery, Chosun University Hospital, 365 Pilmundae-ro, Dong-gu, Gwangju 61453, Republic of Korea.
Managing periprosthetic femoral fractures is challenging, particularly in osteoporotic patients with fragile bones. Revision with a long stem is commonly considered but may fail to provide adequate fixation and stability in fragile bones. A novel approach using sandwiched strut allografts and controlled bone crushing with robust cable fixation can offer mechanical support and provide secondary stability to the loosened femoral stem and can be considered a treatment option for low-demand patients.
View Article and Find Full Text PDFRescue of Mutant CFTR Channel Activity by Investigational Co-Potentiator Therapy.
Biomedicines
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Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, 1749-016 Lisbon, Portugal.
The potentiator VX-770 (ivacaftor) has been approved as a monotherapy for over 95 cystic fibrosis (CF)-causing variants associated with gating/conductance defects of the CF transmembrane conductance regulator (CFTR) channel. However, despite its therapeutic success, VX-770 only partially restores CFTR activity for many of these variants, indicating they may benefit from the combination of potentiators exhibiting distinct mechanisms of action (i.e.
View Article and Find Full Text PDFGoal Achievement and Academic Dropout Among Italian University Students: The Mediating Role of Academic Burnout.
Eur J Investig Health Psychol Educ
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Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.
As stated by the Goal Orientation Theory, students want to achieve a goal for multiple reasons, with each having a different impact on academic performance. This framework encompasses a three-factor model of goal achievement: a mastery goal, a performance-avoidance (PAv) goal, and a performance-approach (PAp) goal. Students may experience elevated stress levels and burnout due to adopting an ineffective approach to goal achievement.
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