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The assessment of humans indirectly exposed to chemicals via the environment (HvE) is an assessment element of the Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH) regulation. The European Union System for the Evaluation of Substances (EUSES) is the default screening tool, aimed at prioritizing chemicals for further refinement/higher tier assessment. This review summarizes the approach used in EUSES, evaluates the state of the science in human exposure modeling via the environment, and identifies areas for further research to strengthen the confidence and applicability of EUSES for assessing HvE.

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Freshwater ecotoxicity characterization factors for PFASs.

Integr Environ Assess Manag

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Environmental Systems Analysis, Chalmers University of Technology, Gothenburg, Sweden.

This research aims to address the data gaps in freshwater ecotoxicological characterization factors (CFs) for per- and polyfluoroalkyl substances (PFASs). These CFs are essential for incorporating the ecotoxicity impacts of PFAS emissions into life cycle assessments (LCAs). This study has three primary objectives: first, to calculate a comprehensive set of experimental aquatic ecotoxicity CFs for PFASs utilizing the USEtox model (version 2.

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