Recent advances in the development of data structures to represent spiking neuron network models enable us to exploit the complete memory of petascale computers for a single brain-scale network simulation. In this work, we investigate how well we can exploit the computing power of such supercomputers for the creation of neuronal networks. Using an established benchmark, we divide the runtime of simulation code into the phase of network construction and the phase during which the dynamical state is advanced in time. We find that on multi-core compute nodes network creation scales well with process-parallel code but exhibits a prohibitively large memory consumption. Thread-parallel network creation, in contrast, exhibits speedup only up to a small number of threads but has little overhead in terms of memory. We further observe that the algorithms creating instances of model neurons and their connections scale well for networks of ten thousand neurons, but do not show the same speedup for networks of millions of neurons. Our work uncovers that the lack of scaling of thread-parallel network creation is due to inadequate memory allocation strategies and demonstrates that thread-optimized memory allocators recover excellent scaling. An analysis of the loop order used for network construction reveals that more complex tests on the locality of operations significantly improve scaling and reduce runtime by allowing construction algorithms to step through large networks more efficiently than in existing code. The combination of these techniques increases performance by an order of magnitude and harnesses the increasingly parallel compute power of the compute nodes in high-performance clusters and supercomputers.
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http://dx.doi.org/10.3389/fninf.2017.00030 | DOI Listing |
Comp Biochem Physiol Part D Genomics Proteomics
December 2024
Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), School of Life Science, Southwest University, Fisheries Engineering Institute, Chinese Academy of Fishery Sciences, Chongqing 400715, PR China. Electronic address:
Myostatin (Mstn) negatively regulates muscle growth and Mstn deficiency induced "double-skeletal muscle" development in vertebrates, including tilapias. In this study, we performed a transcriptomic analysis of skeletal muscle from both wild-type and mstnb males to investigate the molecular mechanisms underlying skeletal muscle hypertrophy in mstnb mutants. We identified 4697 differentially expressed genes (DEGs), 113 differentially expressed long non-coding RNAs (DE lncRNAs), 211 differentially expressed circular RNAs (DE circRNAs), and 98 differentially expressed microRNAs (DE miRNAs).
View Article and Find Full Text PDFBMJ Paediatr Open
December 2024
Community Child Health, Royal Free London NHS Foundation Trust Children's Services, London, UK
People seeking asylum and refugees living in initial accommodation in the UK can experience significant barriers to accessing care. They often have complex health and social needs and may experience fragmentation in the delivery of services. The Respond Integrated Refugee Health Service, hosted by University College London Hospital and operating across North Central London, has been created to address some of these challenges.
View Article and Find Full Text PDFBMJ Open
December 2024
Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Introduction: Children represent a large and vulnerable patient group. However, the evidence base for most paediatric diagnostic and therapeutic procedures remains limited or is often inferred from adults. There is an urgency to improve paediatric healthcare provision based on real-world evidence generation.
View Article and Find Full Text PDFStud Hist Philos Sci
December 2024
UCL Department of Science and Technology Studies (STS), 22 Gordon Sq, London, WC1H 0AW, UK. Electronic address:
Recently, John McCaskey (2020) has proposed that the arrival of Daniel Fahrenheit's thermometers precipitated the eighteenth-century conceptual change of temperature. I examine the usage of the temperature term in the Philosophical Transactions for this period, leading from the creation of the Fahrenheit thermometer up to the first employment of numerical temperature within the journal, in which temperature is constituted by a numerical value. I identify four strands linking thermometry and meteorology to temperature's conceptual change: the weather data network of James Jurin; the dissemination and acclaim for Fahrenheit thermometers; a resurgence in the usage of temperature in meteorological writing; and both exploratory usage and a broadening of the term's extent as it realigned to thermometry.
View Article and Find Full Text PDFRisk Manag Healthc Policy
December 2024
Department of Health Management and Policy, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon.
The interrelationality of health and peace is complex, multifactorial, and imbued with political and economic challenges. Peace and health outcomes reflect shared fundamental values related to the achievement of a balanced holistic condition on the individual and collective level. This causal relationship between social inequity and health requires special attention be paid to the impact of political instability and structural violence on undermining health systems in conflict zones.
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