AI Article Synopsis
- Selenoprotein-related myopathy (S-BM) is a rare muscular disease linked to mutations in the selenoprotein N1 gene and can manifest in various ways.
- Two children aged 7 and 12 with S-BM experienced sleep-disordered breathing (SDB) but showed significant improvement with long-term nocturnal noninvasive ventilation.
- The study recommends regular screening for SDB in S-BM patients through nocturnal polysomnography, as there's no clear connection between the timing of SDB onset and other symptoms like pulmonary function or muscle weakness.
Article Abstract
Selenoprotein-related myopathy (-RM) is a rare disease with a variable clinical presentation. The selenoprotein N1 gene () mutation causing this congenital muscular dystrophy was identified in 2001. Sleep-disordered breathing (SDB) may occur in young patients with -RM who are still able to walk. We report the cases of two children with -RM who presented with SDB at the ages of 7 and 12 years and for whom long-term nocturnal noninvasive ventilation yielded significant improvement. Based on literature review and our current cases, it seems that there is no obvious relationship between the time since SDB onset and outcome of pulmonary function tests or limb muscle weakness. We therefore suggest that SDB should be systematically screened for in patients with -RM, at regular intervals using nocturnal polysomnography.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566467 | PMC |
| http://dx.doi.org/10.5664/jcsm.6734 | DOI Listing |
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