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| http://dx.doi.org/10.1097/ADM.0000000000000283 | DOI Listing |
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The branched-chain amino acid-related isoleucic acid: recent research advances.
Plant Biol (Stuttg)
January 2025
Department of Environmental Health, Institute of Biochemical Plant Pathology, Helmholtz Zentrum München, Neuherberg, Germany.
Isoleucic acid (ILA) was identified in human patients with maple syrup urine disease (MSUD) half a century ago. MSUD patients, who are defective in the catabolism of branched-chain amino acids (BCAAs), that is, isoleucine, leucine, and valine, have urine with a unique maple syrup odour related to the accumulation of BCAA breakdown products, largely 2-keto acid derivatives and their reduced 2-hydroxy acids including ILA. A decade ago, ILA was identified in Arabidopsis thaliana.
View Article and Find Full Text PDFCombination Oxylanthanum Carbonate and Tenapanor Lowers Urinary Phosphate Excretion in Rats.
Kidney360
January 2025
Unicycive Therapeutics, Los Altos, CA, United States.
Background: This study evaluated the combined effects of oxylanthanum carbonate (OLC), an investigational phosphate binder, and tenapanor, an approved sodium/hydrogen exchanger 3 (NHE3) inhibitor that reduces paracellular phosphate absorption, on urinary phosphate excretion in rats on a high phosphorus diet.
Methods: Sixty-four male Sprague Dawley rats were randomized into eight groups: vehicle; tenapanor (0.15 mg/kg) only; OLC (0.
A two-dimensional fluorescence and chemiluminescence orthogonal probe for discriminating and quantifying similar proteins.
Chem Sci
January 2025
Key Laboratory for Advanced Materials, Institute of Fine Chemicals, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, Center of Photosensitive Chemicals Engineering, East China University of Science and Technology Shanghai 200237 China
Given that proteins with minor variations in amino acid sequences cause distinct functional outcomes, identifying and quantifying similar proteins is crucial, but remains a long-standing challenge. Herein, we present a two-dimensional orthogonal fluorescence and chemiluminescence design strategy for the probe DCM-SA, which is sequentially activated by albumin-mediated hydrolysis, exhibiting light-up fluorescence and photo-induced cycloaddition generating chemiluminescence, enabling orthogonal signal amplification for discrimination of subtle differences between similar proteins. By orthogonalizing these dual-mode signals, a two-dimensional work curve of fluorescence and chemiluminescence is established to distinguish and quantify similar proteins HSA and BSA.
View Article and Find Full Text PDFLiquid biopsy in cancer management: Integrating diagnostics and clinical applications.
Pract Lab Med
January 2025
Department of Pharmaceutical Sciences, School of Pharmaceutical Science, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, 226025, Lucknow, India.
Liquid biopsy is an innovative, minimally invasive diagnostic tool revolutionizing cancer management by enabling the detection and analysis of cancer-related biomarkers from bodily fluids such as blood, urine, or cerebrospinal fluid. Unlike traditional tissue biopsies, which require invasive procedures, liquid biopsy offers a more accessible and repeatable method for tracking cancer progression, detecting early-stage cancers, and monitoring therapeutic responses. The technology primarily focuses on analyzing circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and other cancer-derived genetic materials.
View Article and Find Full Text PDFEfficacy of traditional Chinese medicine as an adjunctive treatment in patients with renal dysfunction: a systematic-review and meta-analysis.
Front Med (Lausanne)
January 2025
Department of Central Laboratory, Shenzhen Hospital, Beijing University of Chinese Medicine, Shenzhen, Guangdong, China.
Objective: The effectiveness of using as an adjuvant therapy for patients with renal dysfunction (RD), especially acute kidney injury (AKI), is still a topic of debate. In response to the current conflicting data, the present meta-analysis was conducted to assess the clinical effectiveness of in the treatment of RD and to provide evidence for clinical practice.
Methods: Several databases, including PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and Wanfang, were systematically searched updated to March 25, 2024.
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