Contrast agents for multimodal imaging are in high demand for cancer diagnosis. To date, integration of T/T-weighted magnetic resonance imaging (MRI) and X-ray computed tomography (CT) imaging capabilities in one system to obtain an accurate diagnosis still remains challenging. In this work, biocompatible PEGylated GdF:Fe nanoparticles (PEG-GdF:Fe NPs) were reasonable designed and synthesized as multifunctional contrast agents for efficient T/T-weighted MRI and X-ray CT multimodal imaging. Owing to the enhanced permeability and retention effect in vivo, strong T contrast, evident T contrast, and X-ray CT signals in a tumor lesion can be observed after intravenous injection of PEG-GdF:Fe NPs. Therefore, PEG-GdF:Fe NPs could be used as potential multimodal contrast agents for cancer diagnosis.
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| http://dx.doi.org/10.1021/acsami.7b04438 | DOI Listing |
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