AI Article Synopsis
- Fluorine-19 (F) has high NMR sensitivity similar to protons, but it is rare in biological systems, allowing for cleaner signals in imaging and spectroscopy.
- Researchers explored hyperpolarizing F nuclei using parahydrogen gas, resulting in a significant increase in NMR signal intensity for 3-fluoropyridine.
- This study shows promising capabilities for hyperpolarized F imaging and pH sensing, with potential for further optimization to enhance sensitivity.
Article Abstract
Fluorine-19 has high NMR detection sensitivity-similar to that of protons-owing to its large gyromagnetic ratio and high natural abundance (100 %). Unlike protons, however, fluorine-19 ( F) has a negligible occurrence in biological objects, as well as a more sensitive chemical shift. As a result, in vivo F NMR spectroscopy and MR imaging offer advantages of negligible background signal and sensitive reporting of the local molecular environment. Here we report on NMR hyperpolarization of F nuclei using reversible exchange reactions with parahydrogen gas as the source of nuclear spin order. NMR signals of 3-fluoropyridine were enhanced by ≈100 fold, corresponding to 0.3 % F nuclear spin polarization (at 9.4 T), using about 50 % parahydrogen. While future optimization efforts will likely significantly increase the hyperpolarization levels, we already demonstrate the utility of F hyperpolarization for high-resolution hyperpolarized F imaging and hyperpolarized F pH sensing.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cphc.201700594 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!