A novel conductive DNA-based nanomaterial, DNA-peptide wire, composed of a DNA core and a peripheral peptide layer, is presented. The electrical conductivity of the wire is found to be at least three orders in magnitude higher than that of native double-stranded DNA (dsDNA). High conductivity of the wires along with a better resistance to mechanical deformations caused by interactions between the substrate and electrode surface make them appealing for a wide variety of nanoelectronic and biosensor applications.
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http://dx.doi.org/10.3390/nano7060128 | DOI Listing |
Angew Chem Int Ed Engl
January 2025
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
A method to photomodulate dynamically transient DNA-based reaction circuits and networks is introduced. The method relies on the integration of photoresponsive o-nitrobenzyl-phosphate ester-caged DNA hairpin with a "mute" reaction module. Photodeprotection (λ=365 nm) of the hairpin structure separates a fuel strand triggering the dynamic, transient, operation of the DNA circuit/network.
View Article and Find Full Text PDFBiosens Bioelectron
December 2024
Department of Gastroenterology, Hubei Key Laboratory of Tumor Biological Behavior, Zhongnan Hospital of Wuhan University, Wuhan, 430072, PR China; Research Institute of Shenzhen, Wuhan University, Shenzhen, 518057, PR China. Electronic address:
Biomolecules play essential roles in regulating the orderly progression of biochemical reaction networks. DNA-based biocircuits supplement an attractive and ideal approach for the visual imaging of endogenous biomolecules, yet their sensing performance is commonly encumbered by the undesired signal leakage. To solve this issue, here we proposed a glutathione (GSH)-activated DNA circuit for achieving the spatio-selective microRNA imaging through the successive response of a GSH-specific activation procedure and a non-enzymatic catalytic signal amplification procedure.
View Article and Find Full Text PDFFront Oncol
December 2024
Department of Pathology, China-Janpan Friendship Hospital, Beijing, China.
Background: Anaplastic lymphoma kinase () rearrangement, the most common oncogenic rearrangement in lung adenocarcinoma, occurs in approximately 5% of non-small cell lung cancer (NSCLC) patients. gene is the most common partner of rearrangement, and distinct EML4-ALK fusions differ in their responsiveness to ALK tyrosine kinase inhibitors. However, the concurrence of two rearrangements in one patient and whose response to ALK-TKIs have rarely been reported so far.
View Article and Find Full Text PDFPLoS One
December 2024
Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America.
Vocalizations are one of the key premating reproductive barriers that could affect species formation. In song-learning birds, vocal traits are sometimes overlooked in species delimitation, as compared to morphological or plumage-based differences. In this study, we assessed geographic variation in songs of eight pairs of oscines on two scales: (1) comparing primary songs of species/subspecies pairs whose breeding grounds are eastern and western counterparts of each other in the continental North America, and (2) for each counterpart, identifying and comparing possible variation among their populations.
View Article and Find Full Text PDFSmall
December 2024
Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Raman spectroscopy (RS) has emerged as a novel optical imaging modality by identifying molecular species through their bond vibrations, offering high specificity and sensitivity in molecule detection. However, its application in intracellular molecular probing has been limited due to challenges in combining vibrational tags with functional probes. DNA nanostructures, known for their high programmability, have been instrumental in fields like biomedicine and nanofabrication.
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