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Determinants of Human Corneal Mechanical Wave Dispersion for In Vivo Optical Coherence Elastography.
Transl Vis Sci Technol
January 2025
College of Optometry, University of Houston, Houston, TX, USA.
Purpose: To characterize frequency-dependent wave speed dispersion in the human cornea using microliter air-pulse optical coherence elastography (OCE), and to evaluate the applicability of Lamb wave theory for determining corneal elastic modulus using high-frequency symmetric (S0) and anti-symmetric (A0) guided waves in cornea.
Methods: Wave speed dispersion analysis for transient (0.5 ms) microliter air-pulse stimulation was performed in four rabbit eyes ex vivo and compared to air-coupled ultrasound excitation.
Pallidothalamic Circuit-Selective Manipulation Ameliorates Motor Symptoms in A Rat Model of Parkinsonian.
J Neurosci
January 2025
Department of Biomedical Engineering, Michigan Technological University, 1400 Townsend Dr. Houghton, MI 49931.
Deep brain stimulation (DBS) effectively treats motor symptoms of advanced Parkinson's disease (PD), with the globus pallidus interna (GPi) commonly targeted. However, its therapeutic mechanisms remain unclear. We employed optogenetic stimulation in the entopeduncular nucleus (EP), the rat homologue of GPi, in a unilateral 6-OHDA lesioned female Sprague Dawley rat model of PD.
View Article and Find Full Text PDFVolumetric Passive Acoustic Mapping and Cavitation Detection of Nanobubbles under Low-Frequency Insonation.
ACS Mater Au
January 2025
Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 6997801, Israel.
Gas bubbles, commonly used in medical ultrasound (US), witness advancements with nanobubbles (NB), providing improved capabilities over microbubbles (MB). NBs offer enhanced penetration into capillaries and the ability to extravasate into tumors following systemic injection, alongside prolonged circulation and persistent acoustic contrast. Low-frequency insonation (<1 MHz) with NBs holds great potential in inducing significant bioeffects, making the monitoring of their acoustic response critical to achieving therapeutic goals.
View Article and Find Full Text PDFMitochondrial DNA mutations in human oocytes undergo frequency-dependent selection but do not increase with age.
bioRxiv
December 2024
Department of Biology, Penn State University, University Park, PA 16802, USA.
Mitochondria, cellular powerhouses, harbor DNA (mtDNA) inherited from the mothers. MtDNA mutations can cause diseases, yet whether they increase with age in human germline cells-oocytes-remains understudied. Here, using highly accurate duplex sequencing of full-length mtDNA, we detected mutations in single oocytes, blood, and saliva in women between 20 and 42 years of age.
View Article and Find Full Text PDFMetapopulation heterogeneities in host mobility, productivity, and immunocompetency always increase virulence and infectiousness.
Proc Natl Acad Sci U S A
December 2024
Complexity Science and Evolution Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Tancha, Onna, Kunigami, Okinawa 904-0495, Japan.
The epidemiology and evolution of diseases unfold in populations that are rarely homogeneous. Instead, hosts infected by pathogens often form metapopulations, in which local populations connected by the movement of hosts experience different demographic and epidemiological conditions. Here, we develop a general theory of the evolution of pathogens in heterogeneous metapopulations.
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