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Enhanced detection and Characterization of M-proteins in multiple myeloma patients using An Agilent AssayMAP Bravo liquid handling system coupled to an LC-QTOF.
Clin Biochem
December 2024
Department of Pathology and Laboratory Medicine, London Health Sciences Centre and St. Joseph's Health Care London, London, ON, Canada; Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Background: Mass spectrometry methods are emerging as tools to detect M-proteins in the serum of multiple myeloma patients with increased sensitivity and specificity compared to traditional electrophoretic methods.
Methods: A liquid handling system, the Agilent AssayMAP Bravo, with liquid chromatography high-resolution quadrupole-time-of-flight (LC-QTOF) mass spectrometry to analyze intact light chains was compared to immunofixation electrophoresis (IFE) for M-protein analysis. 210 patient serum samples were analyzed in a split sample comparison (LC-QTOF vs.
A previously developed algorithm for the preliminary identification of protein proteoforms associated with post-translational modifications (PTMs) based on 2D electrophoresis data (DOI: 10.18097/BMCRM00191) has been used in this study for analysis of experimental data obtained using mice and reported in two papers by different authors. The authors of the first paper identified 8 groups of spots on 2D electrophoretic maps corresponding to 8 proteins with at least two unconcretised proteoforms.
View Article and Find Full Text PDFElectrophoretic deposition of chitosan/gelatin/hydroxyapatite nanocomposite coatings on 316 L stainless steel for biomedical applications.
Biomed Mater
December 2024
Department of Nanomaterials and Nanocoatings, Institute for Color Science and Technology, Tehran, Iran.
In addition to the basic and main parts of hospital equipment, 316 L stainless steel is widely utilized in futures such as nails and screws, wires and medical bone clips, dental implants, heart springs (stents), needles, surgical scissors, etc. In the present study, the electrophoretic deposition of a composite based on chitosan (CS), gelatin, nano and microparticles of hydroxyapatite on a 316 L stainless steel substrate was investigated. Hydroxyapatite particles are added to it due to the ossification abilities of steel and due to an enhanced adhesion and bone production, CS and biocompatible gelatin polymer particles were also added to hydroxyapatite.
View Article and Find Full Text PDFUnexpected proteins involved in the regulation of secondary metabolism in Myxococcus xanthus DK1622.
Biotechnol Appl Biochem
November 2024
Department of Molecular Biology, Kurdistan Institution for Strategic Studies and Scientific Researche, Alley 60, Gullabax 335, Shorsh St., Sulaymaniyah, Iraq.
Regulating secondary metabolite (SM) in Myxococcus xanthus bears the potential to influence the formation of important natural products with various biological activities. The authors of this study have previously found that the detectable levels of two proteins (4-hydroxyphenylpyruvate dioxygenase [HppD] and a Hsp90-like protein [HtpG]) are affected by ROK inactivation. As evidence, the current study was designed to elucidate the possible role of these two proteins in regulating the SMs' biosynthesis in this bacterium.
View Article and Find Full Text PDFThe peroxidase gene OsPrx114 activated by OsWRKY50 enhances drought tolerance through ROS scavenging in rice.
Plant Physiol Biochem
October 2023
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Ministry of Agriculture Key Laboratory for Plant Protection and Biotechnology, Zhejiang Provincial Key Laboratory of Plant Virology, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, China. Electronic address:
Article Synopsis
- Drought is a major environmental challenge for plants, and this study focuses on the gene OsPrx114, which helps plants cope with drought by being activated under stress conditions.
- The OsPrx114 gene is located in crucial cell structures and contains specific elements that aid in drought resistance, leading to lowered production of harmful reactive oxygen species (ROS) when overexpressed.
- The gene's activation is regulated by the transcription factor OsWRKY50, which binds to its promoter and enhances its ability to enhance drought tolerance in rice.
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