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http://dx.doi.org/10.1111/j.1558-5646.1984.tb00366.x | DOI Listing |
ACS Omega
January 2025
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, 00433 Nablus, Palestine.
Currently, available therapies for diabetes cannot achieve normal sugar values in a high percentage of treated patients. This work synthesized a series of carbazole-triazole-thione derivatives, and their potential antidiabetic activity was investigated against the key diabetic enzymes α-amylase and glycosidase. Normal human hepatic stellate cells (LX-2) were employed to assess their cytotoxicity and safety, followed by in vivo testing to investigate the hypoglycemic effect of the most promising agent.
View Article and Find Full Text PDFAm J Physiol Regul Integr Comp Physiol
January 2025
College of Life and Health Sciences, Chubu University, Kasugai, Japan.
Persistent stressful situations can have detrimental cardiovascular effects; however, effects on the blood pressure (BP) response to exercise have not been fully examined. This study investigated the impact of a 2-week stressful situation on the exercise pressor response. Eight healthy male university paramedic trainees underwent a 2-week paramedic hospital training and a control period study.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Dept. of Chemistry, Netaji Subhas University of Technology (N.S.U.T.), erstwhile N.S.I.T., Azad Hind Fauj Marg, Dwarka, Delhi 110078, India. Electronic address:
This study aims to enhance the antidiabetic potential of Vanadium pentoxide (VO) by synthesizing chitosan-based nanoparticles (NPs). Chitosan and its derivatives were used to fabricate VO NPs, ensuring enhanced antioxidant and antidiabetic activity. Surface topography was analyzed using atomic force microscopy (AFM), revealing bioactive sites on the NPs with improved electron-transfer capability, as confirmed by cyclic voltammetry (CV).
View Article and Find Full Text PDFBioorg Chem
January 2025
Department of Pharmacy, University of Genoa, Viale Benedetto XV, 3, Genoa 16132, Italy. Electronic address:
Diabetes mellitus has dominated the globe as a chronic health condition and has become a major global health concern. The inhibition of the key metabolic enzymes of carbohydrates digestion including α-amylase and α-glucosidase are the promising targets for the treatment of diabetes via delaying glucose absorption. Therefore, nitrogen containing saturated heterocycle (pyrrolidinyl, piperidinyl and N-methylpiperazinyl) based hydrazones derivatives 5-23 were synthesized through two step reactions and evaluated for their anti-diabetic potential.
View Article and Find Full Text PDFUltrason Sonochem
January 2025
School of Food and Biological Engineering Jiangsu University, Zhenjiang, Jiangsu 212013, China. Electronic address:
This research aimed to evaluate the effect of triple-frequency ultrasound treatment (TFUT), germination (GE), and traditional soaking (TS) methods on the nutritional and techno-functional properties of two different barley varieties, including ZQ2000 and XMLY22. Both ZQ2000 and XMLY22 varieties exhibited the highest total phenolic content (TPC) with 840.73 ± 23.
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