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Unveiling soil-borne antibiotic resistome and their associated risks: A comparative study of antibiotic and non-antibiotic pharmaceutical factories.
J Hazard Mater
January 2025
Key Laboratory of Recycling and Eco-Treatment of Waste Biomass of Zhejiang Province, School of Environmental and Natural Resource, Zhejiang University of Science and Technology, Hangzhou, Zhejiang 310023, China.
Antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria (ARB) are extensively documented within antibiotic pharmaceutical factories. Notably, non-antibiotic pharmaceuticals also represent a significant portion of the pharmaceuticals market. However, the comparative analyses of soil-borne ARG profiles and associated risks in different categories of pharmaceutical factories remain limited.
View Article and Find Full Text PDFComparative analysis of hospital laboratory wastewater treatment techniques in Syrian Arab Republic.
East Mediterr Health J
December 2024
Department of Basic Sciences, Faculty of Civil Engineering, University of Aleppo, Aleppo, Syria.
Background: Hospital wastewater poses a significant threat to human health due to the presence of difficult-to-degrade organic compounds, active pharmaceutical ingredients and multiple inorganic substances that can pollute water resources and ecosystems.
Aim: To compare the effectiveness of different techniques for removing organic load from hospital laboratory wastewater in Aleppo, Syria.
Methods: We treated wastewater samples from hospital laboratories at Aleppo University Hospital, Syria, using several techniques, including biological treatment with the rotating biological contactor, adsorption with Syrian natural clay, coagulation with aluminium sulphate, advanced oxidation with ultrasound, and a combined treatment using natural clay and ultrasound.
Simultaneous utilization of CO and potassium-rich biomass for the environmentally friendly production of potassium formate.
RSC Adv
January 2025
Department of Chemistry, Chung-Ang University 84 Heukseok-ro, Dongjak-gu Seoul Republic of Korea
The C chemical species, potassium formate (K(HCO)), known as a two-electron reducing agent, finds application in the synthesis of multi-carbon compounds, including oxalate, and plays a crucial role not only in the food and pharmaceutical industries but also across various sectors. However, the direct hydrogenation of CO to produce K(HCO) remains a challenge. Addressing this issue, efficient production of K(HCO) is achieved by integrating CO hydrogenation in a trickle-bed reactor using a heterogeneous catalyst with a novel separation method that utilizes potassium ions from biomass ash for formic acid derivative product isolation.
View Article and Find Full Text PDFLignocellulose biosorbents: Unlocking the potential for sustainable environmental cleanup.
Int J Biol Macromol
January 2025
Amity Institute of Pharmacy, Amity University Haryana, Amity Education Valley, Panchgaon, Manesar, Gurugram, Haryana 122413, India. Electronic address:
Climate change, the overconsumption of fossil fuels, and rapid population and economic growth have collectively driven a growing emphasis on environmental sustainability and the need for effective resource management. Chemicals or materials not currently regulated are known as contaminants of emergent concern (CECs). Nevertheless, wastewater is thought to be its main source, and worries about its probable presence in the environment are growing due to its potential damage to human and environmental health.
View Article and Find Full Text PDFReal-time monitoring of small changes in powder blends and ejected tablets in a low-dose formulation with 1 %w/w of active pharmaceutical ingredient using Raman and near-infrared spatially resolved spectroscopy within a tablet press.
Int J Pharm
January 2025
Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ, 08854, USA; Center for Structured Organic Particulate Systems (C-SOPS), Cranbury, NJ, 08512, USA.
This study used Raman and near-infrared (NIR) spectroscopy to monitor small real-time changes in powder blends and tablets in low-dose pharmaceutical formulations. The research aims to enhance process analytical technology (PAT) in pharmaceutical manufacturing, ensuring high-quality and uniform products with applications to produce drugs with narrow therapeutic indices (NTI). The study utilizes Raman and NIR spatially resolved spectroscopy (SRS) techniques to monitor a moderate cohesive material's active pharmaceutical ingredient (API) concentrations during manufacturing.
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