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Abdominal foreign body migration causing cardiac tamponade: A case report.
SAGE Open Med Case Rep
October 2024
Department B of Surgery, Charles Nicolle Hospital, Tunis, Tunisia.
Chronic asymptomatic retention of an intragastric foreign body can pose a life-threatening scenario. In the event of migration, it may result in perforation, as shown in our unique case of pericardial perforation through the fundus. Beyond illustrating a rare condition, this case prompts us to engage in a debate about whether to retain or remove asymptomatic foreign bodies in the gastrointestinal tract.
View Article and Find Full Text PDF7-Methylguanine Inhibits Colon Cancer Growth in Vivo.
Acta Naturae
January 2024
Lomonosov Moscow State University, Belozersky Institute of Physicochemical Biology, Moscow, 119991 Russian Federation.
Article Synopsis
- 7-Methylguanine (7-MG) is a natural compound that inhibits key enzymes involved in cancer cell growth.
- Recent studies have shown that 7-MG is safe for use in mice, leading to a specific method for its administration.
- Research indicates that 7-MG effectively enters tumor tissues and reduces the growth of colon adenocarcinoma in various mouse models.
Ninjin'yoeito Modulates Baseline and Reperfusion-Induced Changes in the Arteriole Diameter and Blood Flow in the Cerebral Cortex of Anesthetized Mice.
Microcirculation
October 2024
Department of Autonomic Neuroscience, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Objective: Intragastric administration of ninjin'yoeito (NYT), a traditional Japanese herbal medicine, reportedly prevents the decrease in baseline cerebral blood flow (CBF) in the cortex following gastric administration of water. We investigated the effect of NYT on baseline and dynamic changes in cerebral cortical arteriole diameter.
Methods: Urethane-anesthetized mice were intragastrically administered 1 g/kg NYT or distilled water (DW).
Discovery of an orally effective double-stapled peptide for reducing ovariectomy-induced bone loss in mice.
Acta Pharm Sin B
September 2023
School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Stapled peptides with significantly enhanced pharmacological profiles have emerged as promising therapeutic molecules due to their remarkable resistance to proteolysis and performance to penetrate cells. The all-hydrocarbon peptide stapling technique has already widely adopted with great success, yielding numerous potent peptide-based molecules. Based on our prior efforts, we conceived and prepared a double-stapled peptide in this study, termed FRNC-1, which effectively attenuated the bone resorption capacity of mature osteoclasts through specific inhibition of phosphorylated GSK-3.
View Article and Find Full Text PDFPharmacokinetics, tissue distribution and excretion of six bioactive components from total glucosides picrorhizae rhizoma, as simultaneous determined by a UHPLC-MS/MS method.
J Chromatogr B Analyt Technol Biomed Life Sci
July 2023
College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address:
Total glucosides picrorhizae rhizome (TGPR) is an innovative traditional Chinese medicine, which is a candidate drug for the treatment of nonalcoholic steatohepatitis (NASH). However, there is still lack of deep research on the behaviors of TGPR in vivo. In this study, a reliable, specific, and sensitive liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method has been constructed for simultaneous determination of picroside I, picroside II, vanillic acid, androsin, cinnamic acid and picroside IV, the major active constituents of TGPR, in rat various biological matrices (plasma, tissue, bile, urine and feces) using diphenhydramine hydrochloride and paeoniflorin as the internal standard.
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