The present investigation reports the synthesis of a phenylalanine-rich -methylated cyclopeptide, cordyheptapeptide A (), previously isolated from the insect pathogenic fungus sp. BCC 1788, accomplished through the coupling of -methylated tetrapeptide and tripeptide fragments followed by cyclization of the linear heptapeptide unit. Structure elucidation of the newly synthesized cyclopolypeptide was performed by means of FT-IR, ¹H-NMR, C-NMR, and fast atom bombardment mass spectrometry (FABMS), and screened for its antibacterial, antidermatophytic, and cytotoxic potential. According to the antimicrobial activity results, the newly synthesized -Methylated cyclopeptide exhibited potent antibacterial activity against Gram-negative bacteria and and antifungal activity against dermatophytes and at a concentration of 6 μg/mL, in comparison to the reference drugs, gatifloxacin and griseofulvin. In addition, cyclopolypeptide displayed suitable levels of cytotoxicity against (DLA) and (EAC) cell lines.
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| http://dx.doi.org/10.3390/molecules22060682 | DOI Listing |
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