Gelatin and chitosan were mixed at different mass ratios in solution forms, and the rheological properties of these film-forming solutions, upon cooling, were studied. The results indicate that the significant interactions between gelatin and chitosan promote the formation of multiple complexes, reflected by an increase in the storage modulus of gelatin solution. Furthermore, these molecular interactions hinder the formation of gelatin networks, consequently decreasing the storage modulus of polymer gels. Both hydrogen bonds and electrostatic interactions are formed between gelatin and chitosan, as evidenced by the shift of the amide-II bands of polymers. X-ray patterns of composite films indicate that the contents of triple helices decrease with increasing chitosan content. Only one glass transition temperature (T) was observed in composite films with different composition ratios, and it decreases gradually with an increase in chitosan proportion, indicating that gelatin and chitosan have good miscibility and form a wide range of blends.
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http://dx.doi.org/10.1016/j.foodchem.2017.05.045 | DOI Listing |
Materials (Basel)
January 2025
Department of Fisheries, Faculty of Fisheries and the Environment, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan 4913815739, Iran.
One of the main limitations of biopolymers compared to petroleum-based polymers is their weak mechanical and physical properties. Recent improvements focused on surmounting these constraints by integrating nanoparticles into biopolymer films to improve their efficacy. This study aimed to improve the properties of gelatin-chitosan-based biopolymer layers using zinc oxide (ZnO) and graphene oxide (GO) nanoparticles combined with spermidine to enhance their mechanical, physical, and thermal properties.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Chemistry, Himachal Pradesh University, Shimla 171005, India. Electronic address:
Introduction: The rapid progress in polymer science has designed innovative materials for biomedical applications. In the case of drug design, for each new therapeutic agent, a drug delivery system (DDS) is required to improve its pharmacokinetic and pharmacodynamic parameters. Therefore, significant research has been carried out to develop drug delivery (DD) carriers for these new therapeutic agents.
View Article and Find Full Text PDFBiomed Mater
January 2025
Guangxi Medical University, No.22 Shuangyong Road, Nanning, 530021, CHINA.
Osteoblasts play a critical role in maintaining bone homeostasis. Senescence causes by free radical-mediated oxidative stress may affect the viability and osteogenic differentiation potential of osteoblast during bone formation. To eliminate the impacts of senescent cells by free radical scavenging is an optimal option for bone regeneration in age-related bone disease, such as osteoporosis (OP) and periodontitis.
View Article and Find Full Text PDFBiomed Mater
January 2025
Zhejiang University School of Medicine, 1367 West Wenyi Rd, Hangzhou, 310058, CHINA.
Electrospun membranes with biomimetic fibrous structures and high specific surfaces benefit cell proliferation and tissue regeneration but are prone to cause chronic inflammation and foreign body response (FBR). To solve these problems, we herein report an approach to functionalize electrospun membranes with antibacterial and anti-inflammatory components to modulate inflammatory responses and improve implantation outcomes. Specifically, electrospun polylactic acid (PLA)/gelatin (Gel) fibers were grafted with chitosan (CS) and ibuprofen (IBU) via carbodiimide chemistry.
View Article and Find Full Text PDFBiomed Mater
January 2025
Department of Emergency, Shandong University, Department of Emergency, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, PR China, Jinan, Shandong, 250100, CHINA.
Metallic oxides especially lithium and titanium oxides are well known for their osteogenic properties. When combined in the right proportions, metallic oxides can have an even greater impact. However, releasing ions from oxides can lead to oxidative stress, which is harmful to cell growth.
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