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Network modeling of resting state connectivity points towards the bottom up theories of schizophrenia. | LitMetric

Network modeling of resting state connectivity points towards the bottom up theories of schizophrenia.

Psychiatry Res Neuroimaging

GIN, University of Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux F-33000, France; GIN, CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux F-33000, France; GIN, CEA, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux F-33000, France. Electronic address:

Published: August 2017

AI Article Synopsis

  • The dysconnectivity theory of schizophrenia suggests that symptoms result from abnormal synchronization of neuronal networks, which can be studied using resting-state Functional Connectivity (FC) techniques.
  • This study analyzed the FC strength of 34 resting-state networks in 29 schizophrenia patients and found significant disruptions, leading to weaker connectivity, especially in visual and auditory processing networks.
  • The findings indicate that these disruptions are linked to both positive and negative schizophrenia symptoms, such as hallucinations and delusions, supporting the idea that low-level sensory issues contribute to higher-level cognitive problems in schizophrenia.

Article Abstract

The dysconnectivity theory of schizophrenia proposes that schizophrenia symptoms arise from abnormalities in neuronal synchrony. Resting-state Functional Connectivity (FC) techniques allow us to highlight synchronization of large-scale networks, the Resting-state Networks (RNs). A large body of work suggests that disruption of RN synchronization could give rise to specific schizophrenia symptoms. The present study aimed to explore within- and between-network FC strength of 34 RNs in 29 patients suffering from schizophrenia, and their relationships with schizophrenia symptoms. Resting-state data were analyzed using independent component analysis and dual-regression techniques. Our results showed that both within-RN and between-RN FC were disrupted in patients with schizophrenia, with a global trend toward weaker FC. This decrease affected more particularly visual, auditory and crossmodal binding networks. These alterations were correlated with negative symptoms, positive symptoms and hallucinations, indicating abnormalities in visual processing and crossmodal binding in schizophrenia. Moreover, we stressed an anomalous synchronization between a visual network and a network thought to be engaged in mental imaging processes, correlated with delusions and hallucinations. Altogether, our results supported the assumption that some schizophrenia symptoms may be related to low-order sensory alterations impacting higher-order cognitive processes, i.e. the "bottom-up" hypothesis of schizophrenia symptoms.

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Source
http://dx.doi.org/10.1016/j.pscychresns.2017.04.003DOI Listing

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