AI Article Synopsis
- Recent advancements in optogenetics are revolutionizing drug discovery in neuroscience by linking cellular function to patient health through innovative assays.
- All-optical electrophysiology tools allow for high-throughput analysis of cellular disease models, helping to uncover functional phenotypes related to diseases and potential therapeutic compounds.
- The review highlights the promise of these technologies in various stages of drug discovery, while also addressing ongoing challenges that need to be resolved.
Article Abstract
Recent advances in optogenetics have opened new routes to drug discovery, particularly in neuroscience. Physiological cellular assays probe functional phenotypes that connect genomic data to patient health. Optogenetic tools, in particular tools for all-optical electrophysiology, now provide a means to probe cellular disease models with unprecedented throughput and information content. These techniques promise to identify functional phenotypes associated with disease states and to identify compounds that improve cellular function regardless of whether the compound acts directly on a target or through a bypass mechanism. This review discusses opportunities and unresolved challenges in applying optogenetic techniques throughout the discovery pipeline - from target identification and validation, to target-based and phenotypic screens, to clinical trials.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495001 | PMC |
| http://dx.doi.org/10.1016/j.tibtech.2017.04.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!